果蝇中脂肪体重塑和内稳态控制。

Fat body remodeling and homeostasis control in Drosophila.

机构信息

Division of Human Reproduction and Developmental Genetics, the Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Institute of Genetics, Zhejiang University and Department of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China; College of Life Sciences, Zhejiang University, Hangzhou, China.

Division of Human Reproduction and Developmental Genetics, the Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Institute of Genetics, Zhejiang University and Department of Genetics, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China; Joint Institute of Genetics and Genomic Medicine between Zhejiang University and University of Toronto, Zhejiang University, Hangzhou, Zhejiang, China.

出版信息

Life Sci. 2016 Dec 15;167:22-31. doi: 10.1016/j.lfs.2016.10.019. Epub 2016 Oct 20.

DOI:10.1016/j.lfs.2016.10.019

PMID:27773719

Abstract

Remarkable advances have been made in recent years in our understanding of the Drosophila fat body and its functions in energy storage, immune response and nutrient sensing. The fat body interplays with other tissues to respond to the physiological needs of the body's growth and coordinates various metabolic processes at different developmental stages and under different environmental conditions. The identification of various conserved genetic functions and signaling pathways relating to the Drosophila fat body may provide clues to lipometabolic disease and other aspects of tissue remodeling in humans. Here, we discuss recent insights into how regulation of fat body remodeling contributes to hemostasis with a special focus on how signaling networks and internal physiological states shape different aspects of the lipid metabolism in Drosophila.

摘要

近年来，我们对果蝇体脂肪组织及其在能量储存、免疫反应和营养感应中的功能有了显著的认识。脂肪体与其他组织相互作用，以响应身体生长的生理需求，并协调不同发育阶段和不同环境条件下的各种代谢过程。鉴定与果蝇体脂肪组织相关的各种保守遗传功能和信号通路，可能为脂肪代谢疾病和人类组织重塑的其他方面提供线索。在这里，我们讨论了关于脂肪体重塑如何有助于止血的最新见解，特别关注信号网络和内部生理状态如何塑造果蝇中脂质代谢的不同方面。