Albuterol Improves Alveolar-Capillary Membrane Conductance in Healthy Humans.

BACKGROUND

Beta-2 adrenergic receptors (βARs) are located throughout the body including airway and alveolar cells. The βARs regulate lung fluid clearance through a variety of mechanisms including ion transport on alveolar cells and relaxation of the pulmonary lymphatics. We examined the effect of an inhaled β-agonist (albuterol) on alveolar-capillary membrane conductance (DM) and pulmonary capillary blood volume () in healthy humans.

METHODS

We assessed the diffusing capacity of the lungs for carbon monoxide (DLCO) and nitric oxide (DLNO) at baseline, 30 minutes, and 60 minutes following nebulized albuterol (2.5 mg, diluted in 3 mL normal saline) in 45 healthy subjects. Seventeen subjects repeated these measures following nebulized normal saline (age = 27 ± 9 years, height = 165 ± 21 cm, weight = 68 ± 12 kg, BMI = 26 ± 9 kg/m). Cardiac output (Q), heart rate, systemic vascular resistance (SVR), blood pressure, oxygen saturation, forced expiratory volume at one-second (FEV), and forced expiratory flow at 50% of forced vital capacity (FEF) were assessed at baseline, 30 minutes, and 60 minutes following the administration of albuterol or saline.

RESULTS

Albuterol resulted in a decrease in SVR, and an increase in Q, FEV, and FEF compared to saline controls. Albuterol also resulted in a decrease in at 60 minutes post albuterol. Both albuterol and normal saline resulted in no change in DLCO or DM when assessed alone, but a significant increase was observed in DM when accounting for changes in .

CONCLUSION

These data suggest that nebulized albuterol improves pulmonary function in healthy humans, while nebulization of both albuterol and saline results in an increase in DM/.