癫痫患者的血小板γ-氨基转移酶
Platelet GABA-aminotransferase in epileptic patients.
作者信息
Armijo J A, Arteaga R, Valiente R, Herranz J L
机构信息
Department of Clinical Pharmacology, M. de Valdecilla National Hospital, University of Cantabria, Spain.
出版信息
Int J Clin Pharmacol Res. 1989;9(4):283-5.
Platelet GABA-aminotransferase (GABA-T) activity was determined in 12 adults (six healthy volunteers and six long-term treated epileptic patients) and 17 children (six non-epileptic, and 11 long-term treated epileptic patients). Platelet GABA-T activity was about 60% higher in the epileptic patients than in the controls, both in adults (14.7 +/- 8.6 versus 8.8 +/- 3.5 pmol/min/mg of protein,) and children (13.1 +/- 4.8 versus 8.3 +/- 3.3 pmol/min/mg of protein, p less than 0.05). The relationship between this increase and either epilepsy or anti-epileptic treatment should be clarified in further studies.
测定了12名成年人（6名健康志愿者和6名长期接受治疗的癫痫患者）和17名儿童（6名非癫痫患者和11名长期接受治疗的癫痫患者）的血小板γ-氨基丁酸转氨酶（GABA-T）活性。无论是在成年人中（14.7±8.6对8.8±3.5 pmol/分钟/毫克蛋白质）还是儿童中（13.1±4.8对8.3±3.3 pmol/分钟/毫克蛋白质，p<0.05），癫痫患者的血小板GABA-T活性均比对照组高约60%。这种升高与癫痫或抗癫痫治疗之间的关系应在进一步研究中阐明。
Zotero 插件