School of Biomedical Sciences, The University of Queensland, St Lucia, QLD, 4072, Australia.
Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, 4072, Australia.
Mol Neurobiol. 2017 Nov;54(9):6944-6959. doi: 10.1007/s12035-016-0220-9. Epub 2016 Oct 24.
MicroRNAs (miRNAs) are a class of small non-coding RNA molecules with wide-ranging and subtle effects on protein production. Their activity during the development of the cerebellum provides a valuable exemplar of how non-coding molecules may assist the development and function of the central nervous system and drive neurodevelopmental disorders. Three distinct aspects of miRNA contribution to early cerebellar development will here be reviewed. Aspects are the establishment of the cerebellar anlage, the generation and maturation of at least two principal cell types of the developing cerebellar microcircuit, and the etiology and early progression of autism spectrum disorder. It will be argued here that the autism spectrum is an adept model to explore miRNA impact on the cognitive and affective processes that descend from the developing cerebellum.
微小 RNA（miRNAs）是一类具有广泛而微妙影响蛋白质产生的小非编码 RNA 分子。它们在小脑发育过程中的活性为非编码分子如何帮助中枢神经系统的发育和功能提供了一个有价值的范例，并推动了神经发育障碍的发生。本文将综述 miRNA 对早期小脑发育的三个不同方面的贡献。这三个方面是小脑基板的建立、发育中小脑微电路的至少两种主要细胞类型的产生和成熟，以及自闭症谱系障碍的病因和早期进展。本文认为，自闭症谱系是一个很好的模型，可以探索 miRNA 对源于发育中的小脑的认知和情感过程的影响。
