Gettinby G, Soutar A, Armour J, Evans P
Int J Parasitol. 1989 Jul;19(4):369-76. doi: 10.1016/0020-7519(89)90092-1.
A site-specific genetic prediction model is presented, which examines the influences of different anthelmintic treatment regimens on selecting for drug resistance within a sheep management system. The model exploits the power of modern microcomputers to integrate factors such as parasite strain, geographic location, management practice and genetic fitness to identify effective control regimens which do not lead to resistant Ostertagia circumcincta strains over a 30-year horizon. The potential use of the model as a farm level management-support tool is discussed.
本文提出了一种位点特异性遗传预测模型，该模型研究了不同驱虫治疗方案对绵羊管理系统内耐药性选择的影响。该模型利用现代微型计算机的能力，整合寄生虫菌株、地理位置、管理实践和遗传适应性等因素，以确定在30年时间内不会导致环纹奥斯特线虫菌株产生抗性的有效控制方案。还讨论了该模型作为农场层面管理支持工具的潜在用途。
