Gluba-Brzozka Anna, Franczyk Beata, Bartnicki Piotr, Rysz-Gorzyn Ska Magdalena, Rysz Jacek
Department of Nephrology, Hypertension and Family Medicine, WAM University Hospital of Lodz, Zeromskiego 113, 90-549 Lodz, Poland.
Curr Vasc Pharmacol. 2017;15(2):123-134. doi: 10.2174/1570161114666161021110013.
Chronic kidney disease (CKD) is a worldwide public health problem and an independent risk factor for cardiovascular disease (CVD).
We assessed cardiovascular risk in end-stage renal disease (ESRD) patients and evaluated the relationship between serum uric acid (SUA) and lipoprotein subfractions.
The study group consisted of 66 patients on dialysis and a control group of 25 healthy volunteers. Concentration of high-density lipoproteins (HDL) and low-density lipoproteins (LDL) subfractions were analysed using a Lipoprint™. Lipid profiles and SUA were measured.
There were significant differences in the distribution of HDL1-HDL5 subfractions levels, which were significantly higher in patients with impaired renal function than in the control group (p≤0.013 for all comparisons). HDL7-HDL10 subfractions were significantly more prevalent in healthy volunteers compared with CKD patients (p≤0.001 for all comparisons). The analysis of LDL subfractions revealed significant differences only in IDL-B (p<0.05), IDL-A (p<0.05) and LDL2 (p<0.001) between patients with CKD stage 5 and controls.
Our study demonstrated that higher SUA level might be associated with lower prevalence of CVD among haemodialysis patients. An elevated SUA concentration in haemodialysis population may be a marker of better nutritional status and also represent the antioxidant properties SUA.
慢性肾脏病（CKD）是一个全球性的公共卫生问题，也是心血管疾病（CVD）的独立危险因素。
我们评估了终末期肾病（ESRD）患者的心血管风险，并评估了血清尿酸（SUA）与脂蛋白亚组分之间的关系。
研究组由66名接受透析的患者组成，对照组为25名健康志愿者。使用Lipoprint™分析高密度脂蛋白（HDL）和低密度脂蛋白（LDL）亚组分的浓度。测量血脂谱和SUA。
HDL1-HDL5亚组分水平的分布存在显著差异，肾功能受损患者的水平显著高于对照组（所有比较p≤0.013）。与CKD患者相比，HDL7-HDL10亚组分在健康志愿者中更为普遍（所有比较p≤0.001）。对LDL亚组分的分析显示，CKD 5期患者与对照组之间仅在IDL-B（p<0.05）、IDL-A（p<0.05）和LDL2（p<0.001）方面存在显著差异。
我们的研究表明，较高的SUA水平可能与血液透析患者中较低的CVD患病率相关。血液透析人群中SUA浓度升高可能是营养状况较好的一个标志，也代表了SUA的抗氧化特性。
