Yıldırım Alp, Karakaş Mustafa Serkan, Kılınç Ali Yaşar, Altekin Refik Emre, Yalçınkaya Ali Selim
Department of Cardiology, Kars State Hospital, Kars, Turkey.
Department of Cardiology, Akdeniz University Faculty of Medicine, Antalya, Turkey.
Turk Kardiyol Dern Ars. 2016 Oct;44(7):575-581. doi: 10.5543/tkda.2016.06944.
This study was conducted to evaluate arterial structure and function with assessment of pulse wave velocity (PWV) and carotid intima-media thickness (CIMT) in patients with Behçet's disease (BD).
Thirty patients (13 female, 17 male) with BD and 30 age, sex-matched healthy controls (12 female, 18 male) with no known cardiovascular disease were enrolled in this study. Carotid-femoral PWV and CIMT were measured.
PWV was higher in BD patients compared with control group (6.35±1.05 vs. 5.75±0.83, respectively; p=0.017). There was no significant difference in maximum CIMT (0.751±0.077 mm vs. 0.735±0.079 mm, respectively; p=0.435), or mean CIMT (0.643±0.070 mm vs. 0.629±0.069, respectively; p=0.452). Maximum CIMT, mean CIMT, and PWV were positively correlated with duration of disease (r=0.410, p=0.025; r=0.404, p=0.027; and r=0.362, p=0.049, respectively).
Findings suggest that endothelial function is impaired in cases of BD before visible structural changes to arterial wall. PWV is more useful measurement than CIMT in determination of vascular damage in BD, especially in early stage of disease duration.
本研究旨在通过评估白塞病（BD）患者的脉搏波速度（PWV）和颈动脉内膜中层厚度（CIMT）来评价动脉结构和功能。
本研究纳入了30例BD患者（13例女性，17例男性）和30例年龄、性别匹配且无已知心血管疾病的健康对照者（12例女性，18例男性）。测量了颈动脉-股动脉PWV和CIMT。
BD患者的PWV高于对照组（分别为6.35±1.05和5.75±0.83；p=0.017）。最大CIMT（分别为0.751±0.077mm和0.735±0.079mm；p=0.435）或平均CIMT（分别为0.643±0.070mm和0.629±0.069；p=0.452）无显著差异。最大CIMT、平均CIMT和PWV与疾病持续时间呈正相关（分别为r=0.410，p=0.025；r=0.404，p=0.027；r=0.362，p=0.049）。
研究结果表明，在动脉壁出现可见结构变化之前，BD患者的内皮功能已受损。在确定BD的血管损伤方面，尤其是在疾病持续的早期阶段，PWV比CIMT更有用。
Zotero 插件