Department of Rheumatology, Diskapi Yildirim Beyazit Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
Department of Radiology, Diskapi Yildirim Beyazit Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
Int J Rheum Dis. 2019 May;22(5):781-788. doi: 10.1111/1756-185X.13579. Epub 2019 Apr 15.
We aimed to evaluate subclinical atherosclerosis based on carotid intima-media thickness (CIMT) and arterial stiffness measurements in patients with Behçet's disease (BD), using ultrasound (US) radiofrequency (RF) data technology.
We included 33 BD patients and 33 healthy controls in this study. The participants did not have any primary cardiovascular risk factors, such as diabetes mellitus, hypertension, hyperlipidemia and obesity. All participants were evaluated using Doppler ultrasonography. Arterial stiffness and CIMT measurements were performed in bilateral common carotid arteries using the US RF data technology.
The right, left and mean CIMT values were similar between the patient and control groups (P > 0.05). There was also no statistically significant difference in the right side α and β stiffness indices despite higher values in the patient group (P > 0.05). The right, left and mean distensibility coefficient (DC) and compliance coefficient (CC) values of the patient group were significantly lower than the control group (P < 0.05). The left and mean α- and β-stiffness indices, and the right, left and mean pulse wave velocity (PWV) values were significantly higher in the patient group (P < 0.05). We found higher mean CIMT and PWV values, and α- and β-stiffness indices in patients with mucocutaneous involvement compared with those with major organ involvement, while the mean DC and CC values were lower in the former. However, these results did not reach a statistically significant level.
This study demonstrated evidence of subclinical atherosclerosis in BD in the absence of major atherosclerotic risk factors.
我们旨在使用超声（US）射频（RF）数据技术，评估白塞病（BD）患者基于颈动脉内膜中层厚度（CIMT）和动脉僵硬度测量的亚临床动脉粥样硬化。
我们纳入了 33 名 BD 患者和 33 名健康对照者进行这项研究。所有参与者均无糖尿病、高血压、高脂血症和肥胖等主要心血管危险因素。所有参与者均接受多普勒超声检查。使用 US RF 数据技术，在双侧颈总动脉测量动脉僵硬度和 CIMT。
患者组和对照组的右侧、左侧和平均 CIMT 值相似（P＞0.05）。尽管患者组的右侧α和β僵硬度指数较高，但两组间右侧僵硬度指数无统计学差异（P＞0.05）。患者组的右侧、左侧和平均扩张系数（DC）和顺应性系数（CC）值明显低于对照组（P＜0.05）。患者组的左侧和平均α-和β-僵硬度指数以及右侧、左侧和平均脉搏波速度（PWV）值明显高于对照组（P＜0.05）。我们发现，与主要器官受累的患者相比，有黏膜受累的患者的平均 CIMT 和 PWV 值以及α-和β-僵硬度指数更高，而前者的平均 DC 和 CC 值更低。然而，这些结果没有达到统计学意义。
本研究在无主要动脉粥样硬化危险因素的情况下，证实了 BD 存在亚临床动脉粥样硬化。
