Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), Wuhan, 430074, China.
Department of Dermatology, Union Hospital, Tongji Medical College, HUST, Wuhan, 430022, China.
Angew Chem Int Ed Engl. 2016 Nov 14;55(47):14633-14637. doi: 10.1002/anie.201607982. Epub 2016 Oct 24.
Although high-boiling non-solvent induced macrophase separation in emulsion droplets has been widely applied for the fabrication of polymeric capsules, precise control of their structures remains a great challenge. Herein, block copolymer capsules with tunable shell structures were fabricated by employing a non-solvent as a liquid template in emulsion droplets. The properties of the non-solvents dictate the phase separation sequence in the droplets and the capsule formation mechanism. Two different pathways for capsule formation were observed, and could be applied to predict the shell structure. The structured capsules could be transformed into mesoporous capsules, which demonstrated an intriguing structure-dependent release behavior. Capsules with spherical shell structures displayed the best permeability, while those with lamellar shell structures showed the slowest release, but with a stepwise profile. After loading with an anticancer drug, different capsules induced different apoptosis ratios in cancer cell studies.
尽管高沸点非溶剂诱导的乳液液滴相分离已广泛应用于聚合物胶囊的制备，但对其结构的精确控制仍然是一个巨大的挑战。在此，通过在乳液液滴中使用非溶剂作为液体模板，制备了具有可调壳结构的嵌段共聚物胶囊。非溶剂的性质决定了液滴中的相分离顺序和胶囊形成机制。观察到两种不同的胶囊形成途径，可用于预测壳结构。结构化胶囊可以转化为介孔胶囊，这表现出有趣的结构依赖性释放行为。具有球形壳结构的胶囊显示出最好的渗透性，而具有层状壳结构的胶囊显示出最慢的释放，但具有分步轮廓。在负载抗癌药物后，不同的胶囊在癌症细胞研究中诱导了不同的细胞凋亡率。
