Jia Wenjun, Qi Xin, Li Qi
Department of Cardiology, Tianjin Union Medical Center, Tianjin, China (mainland).
Med Sci Monit. 2016 Oct 24;22:3961-3966. doi: 10.12659/msm.896826.
BACKGROUND Atrial fibrillation (AF) is the most common sustained arrhythmia affected by multiple cardiovascular risk factors. It is reported that caveolin-1 gene (CAV1) rs3807989 polymorphism might be associated with AF risk. The goal of this meta-analysis was to confirm the association between CAV1 rs3807989 polymorphism and susceptibility to AF. MATERIAL AND METHODS We carried out a comprehensive literature search through the electronic databases PubMed, MEDLIN, and Web of Science. We performed a meta-analysis of all selected studies based on CAV1 rs3807989 polymorphism genotypes, including 3758 cases and 6126 controls. RESULTS After meta-analysis with fixed- or random-effects models, we found significant associations in all 5 comparisons: allelic model (G/A; OR=1.228, 95%CI: 1.061-1.420; P=0.006), homozygote model (GG/AA; OR=1.439, 95%CI: 1.094-1.894; P=0.009), heterozygote model (GG/GA; OR=1.257, 95%CI: 1.064-1.486; P=0.007), dominant model (GG/AA+GA; OR=1.287, 95%CI: 1.076-1.540; P=0.006), and recessive model (AA/GA+GG; OR=0.738, 95%CI: 0.629-0.867; P<0.001). Sensitivity analysis results revealed the overall results were robust. CONCLUSIONS The results revealed a significant association between CAV1 gene rs3807989 polymorphism and susceptibility to AF, suggesting that the presence of allelic G might be one of the genetic factors conferring susceptibility to AF. To confirm this association, further well-designed studies are necessary.
心房颤动（AF）是受多种心血管危险因素影响的最常见的持续性心律失常。据报道，小窝蛋白-1基因（CAV1）rs3807989多态性可能与房颤风险相关。本荟萃分析的目的是证实CAV1 rs3807989多态性与房颤易感性之间的关联。材料与方法：我们通过电子数据库PubMed、MEDLIN和Web of Science进行了全面的文献检索。我们基于CAV1 rs3807989多态性基因型对所有选定研究进行了荟萃分析，包括3758例病例和6126例对照。结果：采用固定效应或随机效应模型进行荟萃分析后，我们在所有5种比较中均发现了显著关联：等位基因模型（G/A；OR=1.228，95%CI：1.061-1.420；P=0.006）、纯合子模型（GG/AA；OR=1.439，95%CI：1.094-1.894；P=0.009）、杂合子模型（GG/GA；OR=1.257，95%CI：1.064-1.486；P=0.007）、显性模型（GG/AA+GA；OR=1.287，95%CI：1.076-1.540；P=0.006）和隐性模型（AA/GA+GG；OR=0.738，95%CI：0.629-0.867；P<0.001）。敏感性分析结果显示总体结果稳健。结论：结果显示CAV1基因rs3807989多态性与房颤易感性之间存在显著关联，提示等位基因G的存在可能是赋予房颤易感性的遗传因素之一。为证实这种关联，有必要进行进一步设计良好的研究。
