Borré Etienne, Bellemin-Laponnaz Stéphane, Mauro Matteo
Laboratoire de Chimie et des Biomatériaux Supramoléculaires, Institut de Science et O'Ingénierie Supramoléculaires (ISIS), Université de Strasbourg, CNRS, 8 allée Gaspard Monge, 67083, Strasbourg, France.
Département des Matériaux Organiques, Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Université de Strasbourg, CNRS UMR 7504, 23 rue du Loess, BP 43, 67034, Strasbourg Cedex 2, France.
Chemistry. 2016 Dec 23;22(52):18718-18721. doi: 10.1002/chem.201604321. Epub 2016 Nov 16.
A series of amphiphilic metallopolymers is described that features zinc(II) bis-terpyridine coordination nodes as well as a backbone with hydrophobic azoaryl moieties and hydrophilic phenylene-ethynylene units decorated with PEG brushes. Using such metallopolymers at very low concentration, stable, photo-responsive and self-healing hydrogels are obtained. UV irradiation of the gel allows modulation of the degree of hydrophobic π-π interactions between photoisomerizable azoaryl units and a polarity switch that overall induces a fast gel-to-sol transition. Finally, the material phase can be readily and fully restored to the thermodynamically stable state either thermally or photochemically by using visible light. The presented strategy can be further generalized towards modular supramolecular metallopolymers for injectable gels in drug delivery and bio-engineering applications.
本文描述了一系列两亲性金属聚合物，其特征在于锌（II）双吡啶配位节点，以及具有疏水偶氮芳基部分的主链和装饰有聚乙二醇刷的亲水性亚苯基乙炔单元。在极低浓度下使用此类金属聚合物，可获得稳定、光响应且自愈的水凝胶。凝胶的紫外线照射可调节光异构化偶氮芳基单元之间疏水π-π相互作用的程度以及极性转换，总体上引发快速的凝胶-溶胶转变。最后，通过使用可见光，材料相可以通过热或光化学方式轻松且完全恢复到热力学稳定状态。所提出的策略可进一步推广到用于药物递送和生物工程应用中的可注射凝胶的模块化超分子金属聚合物。
