缺乏充分免疫抑制的多灶性脉络膜炎的疾病进程：一例报告
Course of disease in multifocal choroiditis lacking sufficient immunosuppression: a case report.
作者信息
Schroeder Katharina, Meyer-Ter-Vehn Tobias, Fassnacht-Riederle Heidi, Guthoff Rainer
机构信息
Department of Ophthalmology, University of Duesseldorf, Moorenstr. 5, 40225, Duesseldorf, Germany.
Department of Ophthalmology, University of Wuerzburg, Wuerzburg, Germany.
出版信息
J Med Case Rep. 2016 Oct 24;10(1):298. doi: 10.1186/s13256-016-1069-2.
BACKGROUND
Multifocal choroiditis with panuveitis is a rare disease. The educational merit of this case presentation results from the good documentation and the impressive ocular fundus pictures.
CASE PRESENTATION
We illustrate the 3-year course of disease in a 22-year-old myopic white woman with multifocal choroiditis with panuveitis and secondary choroidal neovascularization. The activity of the disease was evaluated clinically by optical coherence tomography and fluorescein angiography. Choroidal neovascularization was treated by intravitreal bevacizumab (2.5 mg/0.1 ml). Our patient lacked systemic therapy for the first 11 months because of noncompliance.
CONCLUSIONS
The case is remarkable as the delayed onset of peripheral lesions and the additional existence of high myopia made diagnosis difficult. In addition, it demonstrates that full outbreak of disease with multiple central and peripheral fundus lesions and secondary choroidal neovascularization can develop without systemic treatment.
背景
多灶性脉络膜炎伴全葡萄膜炎是一种罕见疾病。本病例报告的教育价值源于良好的记录以及令人印象深刻的眼底照片。
病例报告
我们阐述了一名22岁近视白人女性患多灶性脉络膜炎伴全葡萄膜炎及继发性脉络膜新生血管形成的3年病程。通过光学相干断层扫描和荧光素血管造影对疾病活动进行临床评估。采用玻璃体内注射贝伐单抗（2.5 mg/0.1 ml）治疗脉络膜新生血管。由于患者不依从，在最初11个月未进行全身治疗。
结论
该病例值得关注，因为周边病变延迟出现以及合并高度近视增加了诊断难度。此外，它表明在未进行全身治疗的情况下，可出现伴有多个中央和周边眼底病变及继发性脉络膜新生血管形成的疾病全面发作。
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