Shah C, Zhang W, Xiao Y, Yao L, Zhao Y, Gao X, Liu L, Liu J, Li S, Tao B, Yan Z, Fu Y, Gong Q, Lui S
Radiology Department,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,Zhejiang,China.
Department of Radiology,Huaxi MR Research Center (HMRRC), the Center for Medical Imaging, West China Hospital of Sichuan University,Chengdu,Sichuan,China.
Psychol Med. 2017 Feb;47(3):401-413. doi: 10.1017/S0033291716002683. Epub 2016 Oct 25.
Studies of schizophrenia at drug-naive state and on antipsychotic medication have reported a number of regions of gray-matter (GM) abnormalities but the reports have been inconsistent. The aim of this study was to conduct multimodal meta-analysis to compare the cross-sectional voxel-based morphometry studies of brain GM in antipsychotic-naive first-episode schizophrenia (AN-FES) and those with antipsychotic treatment within 1 year (AT-FES) to determine the similarities and differences in these groups. We conducted two separate meta-analyses containing 24 studies with a sample size of 801 patients and 957 healthy controls. A multimodal meta-analysis method was used to compare the findings between AN-FES and AT-FES. Meta-regression analyses were done to determine the influence of different variables including age, duration of illness, and positive and negative symptom scores. Finally, jack-knife analyses were done to test the robustness of the results. AN-FES and AT-FES showed common patterns of GM abnormalities in frontal (gyrus rectus), superior temporal, left hippocampal and insular cortex. GM in the left supramarginal gyrus and left middle temporal gyrus were found to be increased in AN-FES but decreased in AT-FES, whereas left median cingulate/paracingulate gyri and right hippocampus GM was decreased in AN-FES but increased in AT-FES. Findings suggest that both AN-FES and AT-FES share frontal, temporal and insular regions as common anatomical regions to be affected indicating these to be the primary regions of GM abnormalities in both groups.
针对未服用过药物的精神分裂症患者以及正在服用抗精神病药物的患者的研究报告了许多灰质异常区域，但这些报告并不一致。本研究的目的是进行多模态荟萃分析，以比较未服用过抗精神病药物的首发精神分裂症患者（AN - FES）和在1年内接受过抗精神病药物治疗的患者（AT - FES）基于体素的脑灰质形态学横断面研究，以确定这些组之间的异同。我们进行了两项单独的荟萃分析，包含24项研究，样本量为801例患者和957名健康对照。采用多模态荟萃分析方法比较AN - FES和AT - FES之间的研究结果。进行元回归分析以确定不同变量的影响，包括年龄、病程以及阳性和阴性症状评分。最后，进行留一法分析以检验结果的稳健性。AN - FES和AT - FES在额叶（直回）、颞上叶、左侧海马体和岛叶皮质显示出共同的灰质异常模式。发现左侧缘上回和左侧颞中回的灰质在AN - FES中增加，但在AT - FES中减少，而左侧中央扣带回/旁扣带回和右侧海马体的灰质在AN - FES中减少，但在AT - FES中增加。研究结果表明，AN - FES和AT - FES都将额叶、颞叶和岛叶区域作为共同的受影响解剖区域，表明这些是两组中灰质异常的主要区域。
