Lopez A L, Aldaba J G, Ama C G, Sylim P G, Geraldino X D, Sarol J N, Salonga A M
National Institutes of Health, University of the Philippines Manila, Manila, The Philippines.
Research Institute for Tropical Medicine, Manila, The Philippines.
Int J Tuberc Lung Dis. 2016 Nov;20(11):1495-1500. doi: 10.5588/ijtld.16.0027.
Estimates of the tuberculosis (TB) burden in the Philippines are largely dependent on prevalence surveys.
To conduct a prospective community-based survey to generate epidemiological data on TB among patients seeking care in public health centres in a rural municipality in the Philippines.
Prospective surveillance and follow-up of presumptive TB cases from May 2013 to July 2015.
Of 1622 participants with presumptive TB, 468 (28.8%) (95%CI 26.6-31.1) were diagnosed with TB. The annual TB case notification rate in San Juan was 212 (95%CI 184-242) per 100 000 population. There were nine TB-attributable deaths during the study period. Only 8.8% (95%CI 6.2-11.32) of the cases were children aged <15 years; 274 (58.5%) cases were bacteriologically confirmed. Of 210 isolates tested for antimicrobial resistance, 49 (23.3%, 95%CI 17.58-29.02) were resistant. Resistance to isoniazid (INH) was common (n = 33, 15.7%); multidrug-resistant TB was 1.9%.
TB remains an important health problem in the Philippines. We identified low case detection of TB in children and high INH resistance rates in this rural community.
菲律宾结核病（TB）负担的估计在很大程度上依赖于患病率调查。
开展一项基于社区的前瞻性调查，以获取菲律宾一个农村市镇公共卫生中心寻求治疗的患者中结核病的流行病学数据。
对2013年5月至2015年7月疑似结核病病例进行前瞻性监测和随访。
在1622名疑似结核病参与者中，468人（28.8%）（95%置信区间26.6 - 31.1）被诊断为结核病。圣胡安的年度结核病病例报告率为每10万人口212例（95%置信区间184 - 242）。研究期间有9例结核病相关死亡。病例中仅8.8%（95%置信区间6.2 - 11.32）为15岁以下儿童；274例（58.5%）病例经细菌学确诊。在210株进行耐药性检测的分离株中，49株（23.3%，95%置信区间17.58 - 29.02）耐药。对异烟肼（INH）耐药很常见（n = 33，15.7%）；耐多药结核病为1.9%。
结核病在菲律宾仍然是一个重要的健康问题。我们发现在这个农村社区儿童结核病病例检出率低且异烟肼耐药率高。
