Cunnane Eoghan M, Mulvihill John J E, Barrett Hilary E, Hennessy Mairead M, Kavanagh Eamon G, Walsh Michael T
School of Engineering, Bernal Institute, and the Health Research Institute, University of Limerick, Ireland.
Department of Vascular Surgery, University Hospital Limerick, Limerick, Ireland.
J Biomech. 2016 Nov 7;49(15):3697-3704. doi: 10.1016/j.jbiomech.2016.09.036. Epub 2016 Oct 6.
This study compares the mechanical properties of excised carotid and femoral human plaques and also develops a predictor of these properties based on plaque composition. Circumferential planar tension tests were performed on 24 carotid and 16 femoral plaque samples. Composition was characterised using Fourier Transform Infrared spectroscopy. Stretch at failure, strength, and stiffness are significantly higher in the carotid group (P=.012, P<.001 and P=.002, respectively). The ratio of calcified to lipid plaque content demonstrates the strongest correlation with the stretch at failure and strength (R=.285, P<.001 and R=.347, P<.001). No composition based parameter correlates significantly with stiffness. The significantly different mechanical properties of the two groups aids in explaining the varying endovascular treatment outcomes clinically observed in these vessels. Furthermore, determining the ratio of calcified to lipid plaque content may be useful in predicting individual plaque mechanical response to endovascular treatment.
本研究比较了切除的人类颈动脉和股动脉斑块的力学性能，并基于斑块成分开发了这些性能的预测指标。对24个颈动脉斑块样本和16个股动脉斑块样本进行了周向平面拉伸试验。使用傅里叶变换红外光谱对成分进行了表征。颈动脉组的断裂伸长率、强度和刚度显著更高（分别为P = 0.012、P < 0.001和P = 0.002）。钙化斑块与脂质斑块含量之比与断裂伸长率和强度的相关性最强（R = 0.285，P < 0.001和R = 0.347，P < 0.001）。没有基于成分的参数与刚度有显著相关性。两组力学性能的显著差异有助于解释临床上在这些血管中观察到的不同血管内治疗结果。此外，确定钙化斑块与脂质斑块含量之比可能有助于预测个体斑块对血管内治疗的力学反应。
