Chandran D, Wildermuth M C
Regional Center for Biotechnology, NCR Biotech Science Cluster, Faridabad, India.
University of California, Berkeley, CA, United States.
Enzymes. 2016;40:65-103. doi: 10.1016/bs.enz.2016.09.001. Epub 2016 Oct 7.
Recent studies have revealed that several mutualistic and parasitic biotrophic microbes induce a cell cycle variant termed the endocycle in host cells to support their growth and reproduction. Endoreduplication is a process in which cells successively replicate their genomes without mitosis resulting in an increase in nuclear DNA ploidy. Depending on the interaction, endoreduplication can support biotroph colonization and feeding structure initiation/development, and/or serve as a mechanism to support enhanced metabolic demands of the microbe. When endoreduplication is inhibited in these interactions, biotroph growth or development is compromised. In this review, we summarize the molecular machinery known to mediate endocycle control in plants and highlight the role of these core components in feeding site establishment and/or nutrient acquisition for a diverse set of plant biotrophs.
最近的研究表明，几种互利共生和寄生的活体营养微生物会在宿主细胞中诱导一种称为内循环的细胞周期变体，以支持它们的生长和繁殖。核内复制是一个细胞在不进行有丝分裂的情况下连续复制其基因组的过程，导致核DNA倍性增加。根据相互作用的情况，核内复制可以支持活体营养生物的定殖和取食结构的起始/发育，和/或作为一种机制来支持微生物增加的代谢需求。当在这些相互作用中核内复制受到抑制时，活体营养生物的生长或发育就会受到影响。在这篇综述中，我们总结了已知介导植物内循环控制的分子机制，并强调了这些核心成分在多种植物活体营养生物的取食位点建立和/或养分获取中的作用。
