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Community-onset Klebsiella pneumoniae pneumonia in Taiwan: clinical features of the disease and associated microbiological characteristics of isolates from pneumonia and nasopharynx.台湾社区获得性肺炎克雷伯菌肺炎：疾病的临床特征及肺炎和鼻咽部分离株的相关微生物学特征。
Front Microbiol. 2015 Feb 18;9:122. doi: 10.3389/fmicb.2015.00122. eCollection 2015.
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Clinical characteristics and economic consequence of Klebsiella pneumoniae liver abscess in Taiwan.台湾地区肺炎克雷伯菌肝脓肿的临床特征及经济后果
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Ampicillin and amoxicillin use and the risk of Klebsiella pneumoniae liver abscess in Taiwan.台湾氨苄西林和阿莫西林的使用与肺炎克雷伯菌肝脓肿风险的关系。
J Infect Dis. 2013 Jul 15;208(2):211-7. doi: 10.1093/infdis/jit157. Epub 2013 Apr 8.
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Klebsiella pneumoniae liver abscess in diabetic patients: association of glycemic control with the clinical characteristics.糖尿病患者肺炎克雷伯菌肝脓肿：血糖控制与临床特征的关系。
BMC Infect Dis. 2013 Jan 30;13:56. doi: 10.1186/1471-2334-13-56.
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Standardized outpatient management of Klebsiella pneumoniae liver abscesses.Klebsiella pneumoniae 肝脓肿的标准化门诊管理。
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Klebsiella pneumoniae liver abscess: a new invasive syndrome.肺炎克雷伯菌肝脓肿：一种新的侵袭性综合征。
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Long-term mortality of patients with septic ocular or central nervous system complications from pyogenic liver abscess: a population-based study.化脓性肝脓肿引起的眼部或中枢神经系统并发症患者的长期死亡率：一项基于人群的研究。
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非糖尿病患者肝脓肿的出现及包膜类型分布。

The emergence of liver abscess in non-diabetic patients and the distribution of capsular types.

作者信息

Chuang Chien, Fan Wen-Chien, Lin Yi-Tsung, Wang Fu-Der

机构信息

Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Number 201, Section 2, Shih-Pai Road, Beitou District, Taipei, 11217 Taiwan ; School of Medicine, National Yang-Ming University, Taipei, Taiwan.

出版信息

Gut Pathog. 2016 Oct 18;8:46. doi: 10.1186/s13099-016-0128-y. eCollection 2016.

DOI:10.1186/s13099-016-0128-y
PMID:27777630
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5069856/
Abstract

BACKGROUND

is the most common pathogen of community-acquired pyogenic liver abscess in East Asia. Diabetes mellitus (DM) is a well-established risk factor for liver abscess (KPLA). However, reports regarding the emergence of KPLA in non-diabetic patients are limited.

RESULTS

A total 230 patients with KPLA from a medical center in Taiwan were identified retrospectively. The rate of DM in patients with KPLA was 44.4 % in 2011, 57.9 % in 2012, 44.9 % in 2013, 35.0 % in 2014, and 53.5 % in 2015. Diabetic patients had higher rate of gas-forming abscesses than non-diabetic patients, but the clinical outcomes were not different. The six virulent capsular types (K1, K2, K5, K20, K54, and K57) accounted for 90.2 % of all isolates, and were more prevalent in non-diabetic than diabetic patients (93.9 vs 85.9 %,  = 0.048). The six virulent capsular types were also more prevalent in the group with optimal glycemic levels (Non-DM and DM with HbA1c level <7 %) than the DM group with HbA1c level ≥7 % (93.9 vs 84.3 %,  = 0.022).

CONCLUSION

liver abscess has emerged in non-diabetic patients in Taiwan. Diabetic patients were at higher risk of acquiring gas-forming abscesses. Non diabetic patients and diabetic patients with optimal glycemic levels are more susceptible to the virulent capsular types of .

摘要

背景

在东亚地区，[病原体名称未给出]是社区获得性化脓性肝脓肿最常见的病原体。糖尿病（DM）是肝脓肿（KPLA）公认的危险因素。然而，关于非糖尿病患者发生KPLA的报道有限。

结果

回顾性确定了台湾一家医疗中心的230例KPLA患者。2011年KPLA患者的糖尿病发生率为44.4%，2012年为57.9%，2013年为44.9%，2014年为35.0%，2015年为53.5%。糖尿病患者形成气性脓肿的发生率高于非糖尿病患者，但临床结局并无差异。六种强毒荚膜型（K1、K2、K5、K20、K54和K57）占所有分离株的90.2%，在非糖尿病患者中比糖尿病患者更常见（93.9%对85.9%，P = 0.048）。六种强毒荚膜型在血糖水平最佳组（非糖尿病患者和糖化血红蛋白水平<7%的糖尿病患者）中也比糖化血红蛋白水平≥7%的糖尿病组更常见（93.9%对84.3%，P = 0.022）。

结论

台湾地区非糖尿病患者中出现了KPLA。糖尿病患者发生气性脓肿的风险更高。非糖尿病患者和血糖水平最佳的糖尿病患者更容易感染[病原体名称未给出]的强毒荚膜型。