Liao Chun-Hsing, Huang Yu-Tsung, Hsueh Po-Ren
Department of Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
Department of Medicine, Yang Ming Chiao Tung University, Taipei, Taiwan.
Front Microbiol. 2022 Mar 18;13:783523. doi: 10.3389/fmicb.2022.783523. eCollection 2022.
We conducted a longitudinal epidemiological surveillance of hypervirulent (hvKP) in Taiwan. Bacteremic KP isolates collected from 16 hospitals in Taiwan between 2017 and 2019 were collected, and the virulent serotypes (K1, K2, K20, K54, and K57), antimicrobial susceptibilities, and virulence genes of these isolates were investigated. During the 3-year period, 1,310 bacteremic KP isolates were collected, of which 27.5% belonged to virulent serotypes, including K1 ( = 162), K2 ( = 74), K57 ( = 56), K54 ( = 41), and K20 ( = 27). K1 was the most prevalent capsular serotype, with an annual prevalence of 11-15%, and was equally distributed across the four geographic areas. The prevalence of K2 declined significantly in 2019. According to -K typing results, 87% of K1 isolates were classified as -1. Among K2 isolates, 72 (55.4%) and -2 (41.9%) were the most common, whereas -206 was the most prevalent (48.2%) among K57 isolates, followed by -77 (25.0%). -115 accounted for 85.4% of the K54 isolates, whereas -95 accounted for 92.6% of K20 isolates. was present in 99.4% of K1, 98.6% of K2, 89.3% of K57, 78.0% of K54, and 84.0% of K20 isolates. was present in 100% of K1 and 98.6% of K2 isolates but was only present in 64.3% of K57, 58.5% of K54, and 74.1% of K20 isolates. K1 remains the dominant hvKP serotype and is associated with most virulence genes in Taiwan. Further studies are required to elucidate the significance of other virulent serotypes.
我们在台湾开展了高毒力肺炎克雷伯菌（hvKP）的纵向流行病学监测。收集了2017年至2019年间台湾16家医院分离出的血流感染肺炎克雷伯菌菌株，并对这些菌株的毒力血清型（K1、K2、K20、K54和K57）、抗菌药物敏感性及毒力基因进行了研究。在这3年期间，共收集到1310株血流感染肺炎克雷伯菌菌株，其中27.5%属于毒力血清型，包括K1（=162株）、K2（=74株）、K57（=56株）、K54（=41株）和K20（=27株）。K1是最常见的荚膜血清型，年流行率为11% - 15%，在四个地理区域分布均匀。K2的流行率在2019年显著下降。根据-K分型结果，87%的K1菌株被归类为-1。在K2菌株中，72株（55.4%）和-2（41.9%）最为常见，而在K57菌株中-206最为常见（48.2%），其次是-77（25.0%）。-115占K54菌株的85.4%，而-95占K20菌株的92.6%。分别有99.4%的K1、98.6%的K2、89.3%的K57、78.0%的K54和84.0%的K20菌株携带。分别有100%的K1和98.6%的K2菌株携带，但仅分别有64.3%的K57、58.5%的K54和74.1%的K20菌株携带。K1仍然是台湾地区主要的hvKP血清型，且与大多数毒力基因相关。需要进一步研究以阐明其他毒力血清型的意义。
