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Sulfasalazine induced immune thrombocytopenia in a patient with rheumatoid arthritis.柳氮磺胺吡啶诱发一名类风湿关节炎患者出现免疫性血小板减少症。
Clin Rheumatol. 2017 Feb;36(2):477-479. doi: 10.1007/s10067-016-3420-9. Epub 2016 Oct 24.
2
Sulfasalazine-induced immune thrombocytopenia.柳氮磺胺吡啶诱导的免疫性血小板减少症。
Postgrad Med J. 2007 Jun;83(980):e1. doi: 10.1136/pgmj.2006.055194.
3
[Changes in the blood picture in sulfasalazine therapy of rheumatoid arthritis].[类风湿关节炎柳氮磺胺吡啶治疗中的血象变化]
Z Rheumatol. 1987 Mar-Apr;46(2):86-91.
4
Immune thrombocytopenic purpura associated with rheumatoid arthritis: case report.免疫性血小板减少性紫癜合并类风湿关节炎:病例报告
Clin Rheumatol. 2005 Nov;24(6):641-4. doi: 10.1007/s10067-005-1113-x. Epub 2005 Apr 29.
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[Thrombocytopenia in a patient with rheumatoid arthritis during sulphasalazine therapy].[柳氮磺胺吡啶治疗类风湿关节炎患者时出现的血小板减少症]
Duodecim. 1998;114(17):1731-3.
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Gastric bleeding in a patient with rheumatoid arthritis complicated by immune thrombocytopenic purpura.一名类风湿关节炎合并免疫性血小板减少性紫癜患者的胃出血。
Joint Bone Spine. 2008 May;75(3):350-2. doi: 10.1016/j.jbspin.2007.06.010. Epub 2008 Jan 28.
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Glycoprotein V: the predominant target antigen in gold-induced autoimmune thrombocytopenia.糖蛋白V:金诱导的自身免疫性血小板减少症中的主要靶抗原。
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Four patients with both thrombotic thrombocytopenic purpura and autoimmune thrombocytopenic purpura: the concept of a mixed immune thrombocytopenia syndrome and indications for plasma exchange.4例同时患有血栓性血小板减少性紫癜和自身免疫性血小板减少性紫癜的患者:混合性免疫性血小板减少综合征的概念及血浆置换的指征
J Clin Apher. 2001;16(4):179-85. doi: 10.1002/jca.1031.
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Sulfasalazine in the rheumatic disease.柳氮磺胺吡啶在风湿性疾病中的应用。
Semin Arthritis Rheum. 1988 May;17(4):246-59. doi: 10.1016/0049-0172(88)90010-8.
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[Sulfasalazine in the treatment of rheumatoid arthritis. A multicenter open study of 150 patients during 6 months].[柳氮磺胺吡啶治疗类风湿关节炎。150例患者为期6个月的多中心开放性研究]
Rev Rhum Mal Osteoartic. 1992 Nov 30;59(11):707-13.

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Optical Detection of Fe Ions in Aqueous Solution with High Selectivity and Sensitivity by Using Sulfasalazine Functionalized Microgels.基于柳氮磺吡啶功能化微凝胶的高选择性和高灵敏度水溶液中 Fe 离子的光学检测
Sensors (Basel). 2019 Sep 28;19(19):4223. doi: 10.3390/s19194223.
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Anti-Cancer Effects of Sulfasalazine and Vitamin E Succinate in MDA-MB 231 Triple-Negative Breast Cancer Cells.柳氮磺胺吡啶和维生素 E 琥珀酸酯对 MDA-MB-231 三阴性乳腺癌细胞的抗癌作用。
Int J Med Sci. 2019 Mar 9;16(4):494-500. doi: 10.7150/ijms.30380. eCollection 2019.

本文引用的文献

1
Drug-induced immune thrombocytopenia: incidence, clinical features, laboratory testing, and pathogenic mechanisms.药物性免疫性血小板减少症:发病率、临床特征、实验室检查及发病机制
Immunohematology. 2014;30(2):55-65.
2
Management of thrombocytopenia.血小板减少症的管理
F1000Prime Rep. 2014 Jun 2;6:45. doi: 10.12703/P6-45. eCollection 2014.
3
Guidelines on the use of irradiated blood components prepared by the British Committee for Standards in Haematology blood transfusion task force.英国血液学标准委员会输血工作组制定的辐照血液成分使用指南。
Br J Haematol. 2011 Jan;152(1):35-51. doi: 10.1111/j.1365-2141.2010.08444.x. Epub 2010 Nov 18.
4
Drug-induced immune thrombocytopenia: pathogenesis, diagnosis, and management.药物性免疫性血小板减少症:发病机制、诊断与管理
J Thromb Haemost. 2009 Jun;7(6):911-8. doi: 10.1111/j.1538-7836.2009.03360.x. Epub 2009 Apr 2.
5
Drug-induced immune thrombocytopenia.药物性免疫性血小板减少症
N Engl J Med. 2007 Aug 9;357(6):580-7. doi: 10.1056/NEJMra066469.
6
Sulfasalazine-induced immune thrombocytopenia.柳氮磺胺吡啶诱导的免疫性血小板减少症。
Postgrad Med J. 2007 Jun;83(980):e1. doi: 10.1136/pgmj.2006.055194.
7
The bleeding risk and natural history of idiopathic thrombocytopenic purpura in patients with persistent low platelet counts.血小板持续计数偏低的特发性血小板减少性紫癜患者的出血风险及自然病史。
Arch Intern Med. 2000 Jun 12;160(11):1630-8. doi: 10.1001/archinte.160.11.1630.
8
Drug-induced thrombocytopenia: a systematic review of published case reports.药物性血小板减少症:已发表病例报告的系统评价
Ann Intern Med. 1998 Dec 1;129(11):886-90. doi: 10.7326/0003-4819-129-11_part_1-199812010-00009.
9
Predisposing factors in sulphasalazine-induced systemic lupus erythematosus.柳氮磺胺吡啶诱发系统性红斑狼疮的易感因素。
Br J Rheumatol. 1997 Oct;36(10):1089-94. doi: 10.1093/rheumatology/36.10.1089.

柳氮磺胺吡啶诱发一名类风湿关节炎患者出现免疫性血小板减少症。

Sulfasalazine induced immune thrombocytopenia in a patient with rheumatoid arthritis.

作者信息

Narayan Nehal, Rigby Shirley, Carlucci Francesco

机构信息

Nuffield Orthopaedic Centre, Headington, Oxford, UK.

Warwick Hospital, Warwick, UK.

出版信息

Clin Rheumatol. 2017 Feb;36(2):477-479. doi: 10.1007/s10067-016-3420-9. Epub 2016 Oct 24.

DOI:10.1007/s10067-016-3420-9
PMID:27778097
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5290041/
Abstract

Sulfasalazine has long been used for the treatment of rheumatoid arthritis and is often chosen as a first-line treatment. Here, we report a case of sulfasalazine-induced autoimmune thrombocytopenia and review the mechanisms behind drug-induced immune thrombocytopenia (DITP) and the approach to its diagnosis and management.

摘要

柳氮磺胺吡啶长期以来一直用于治疗类风湿性关节炎,并且常被选作一线治疗药物。在此,我们报告一例柳氮磺胺吡啶诱发的自身免疫性血小板减少症病例,并综述药物性免疫性血小板减少症(DITP)背后的机制及其诊断和管理方法。