Finotello R, Monné Rodriguez J M, Vilafranca M, Altimira J, Ramirez G A, Haines A, Ressel L
Small Animal Teaching Hospital, Institute of Veterinary Sciences, University of Liverpool, Neston, UK.
Section of Veterinary Pathology, Institute of Veterinary Sciences, University of Liverpool, Neston, UK.
Vet Comp Oncol. 2017 Dec;15(4):1393-1402. doi: 10.1111/vco.12281. Epub 2016 Oct 25.
Canine melanoma (CMM) more commonly affects the oral mucosa and the cutis. CMM shares several features with human melanomas (HMM), included resistance to a broad variety of antineoplastic chemotherapy agents. P-glycoprotein 1 (Pgp) expression is a well-recognized feature of multi-drug resistance and the purpose of this study was to investigate its expression in treatment naïve CMM. We also investigated Pgp association with tumour location and histological features. Histology records of CMM were retrieved, including patients from 2012-2014. Twenty-five cases of CMM were included in this study. Results revealed that Pgp is expressed in CMM and oral tumours were more likely to have a membranous Pgp expression (100%) than cutaneous tumours (66.6%) (P = 0.010). Cytoplasmic and nuclear Pgp expression could also be identified. Results of this study bring useful data that help in understanding one of the possible mechanisms responsible of intrinsic chemotherapy resistance in canine CMM.
犬黑色素瘤（CMM）更常累及口腔黏膜和皮肤。CMM与人类黑色素瘤（HMM）有若干共同特征，包括对多种抗肿瘤化疗药物耐药。P-糖蛋白1（Pgp）表达是多药耐药的一个公认特征，本研究旨在调查其在未经治疗的CMM中的表达情况。我们还研究了Pgp与肿瘤位置及组织学特征的关系。检索了CMM的组织学记录，包括2012年至2014年的患者。本研究纳入了25例CMM病例。结果显示，Pgp在CMM中表达，口腔肿瘤比皮肤肿瘤更易出现膜性Pgp表达（100%对66.6%）（P = 0.010）。还可识别出细胞质和细胞核Pgp表达。本研究结果提供了有用数据，有助于理解犬CMM内在化疗耐药的一种可能机制。
