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Repeated loss of target surface antigen after immunotherapy in primary mediastinal large B cell lymphoma.

作者信息

Yu Hui, Sotillo Elena, Harrington Colleen, Wertheim Gerald, Paessler Michele, Maude Shannon L, Rheingold Susan R, Grupp Stephan A, Thomas-Tikhonenko Andrei, Pillai Vinodh

机构信息

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Pennsylvania.

Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Pennsylvania.

出版信息

Am J Hematol. 2017 Jan;92(1):E11-E13. doi: 10.1002/ajh.24594. Epub 2016 Nov 21.

DOI:10.1002/ajh.24594
PMID:27779774
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8620941/
Abstract
摘要

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Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy.获得性突变与CD19可变剪接的趋同导致对CART-19免疫疗法产生抗性。
Cancer Discov. 2015 Dec;5(12):1282-95. doi: 10.1158/2159-8290.CD-15-1020. Epub 2015 Oct 29.
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Evolution to plasmablastic lymphoma evades CD19-directed chimeric antigen receptor T cells.
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Current Insights into CAR T-Cell-Based Therapies for Myelodysplastic Syndrome.基于嵌合抗原受体T细胞疗法治疗骨髓增生异常综合征的最新见解
Pharm Res. 2024 Sep;41(9):1757-1773. doi: 10.1007/s11095-024-03761-8. Epub 2024 Aug 26.
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J Hematop. 2024 Dec;17(4):259-264. doi: 10.1007/s12308-024-00602-w. Epub 2024 Aug 26.
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Blockade of the CD47/SIRPα checkpoint axis potentiates the macrophage-mediated antitumor efficacy of tafasitamab.阻断CD47/SIRPα检查点轴可增强tafasitamab的巨噬细胞介导的抗肿瘤功效。
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