Nalobin D S, Suprunenko E A, Golichenkov V A
M. V. Lomonosov Moscow State University, Moscow, Russia.
Bull Exp Biol Med. 2016 Oct;161(6):845-849. doi: 10.1007/s10517-016-3526-8. Epub 2016 Oct 25.
We studied the effects of melatonin on differentiation potential of Ito cells during atypical regeneration of mouse liver under conditions of CCl-induced fibrosis. The dynamics of fibrosis was traced at the histological level and the effects of melatonin on the differentiation potential of mouse Ito cells were evaluated. Melatonin alleviated fibrotic changes in the liver tissue and reduced differentiation of Ito cells into myofibroblasts under conditions of atypical regeneration of the liver in induced fibrosis. The hepatoprotective role of melatonin was shown.
我们研究了褪黑素对四氯化碳诱导纤维化条件下小鼠肝脏非典型再生过程中肝星状细胞分化潜能的影响。在组织学水平追踪纤维化动态，并评估褪黑素对小鼠肝星状细胞分化潜能的影响。在诱导纤维化的肝脏非典型再生条件下，褪黑素减轻了肝组织中的纤维化变化，并减少了肝星状细胞向肌成纤维细胞的分化。结果显示了褪黑素的肝保护作用。
