Mori T, Itoh E
Nihon Gan Chiryo Gakkai Shi. 1989 May 20;24(5):974-89.
Usefulness of type III procollagen peptide (P-III-P) in sera as tumor marker was investigated in patients with ovarian tumors. A concentration of P-III-P in sera was measured by radioimmunoassay. The mean P-III-P values for 72 females as healthy controls were 8.5 +/- 2.7 ng/ml. Therefore, the cut-off value (Mean + 2 SD) was set at 13.9 ng/ml. The positive rates of healthy controls were 4.2%. For patients with benign ovarian tumors, the mean P-III-P values were 8.7 +/- 2.3 ng/ml, and the positive rates were 0%. For patients with ovarian tumors of borderline malignancy, the mean P-III-P values were 8.0 +/- 1.5 ng/ml, and the positive rates were 0%. In both of benign and borderline malignant cases, the false positive rates of tumor markers such as TPA, IAP, CA-125 and CA 19-9 were relatively high. For patients with malignant ovarian tumors, the mean P-III-P values were 19.7 +/- 9.9 ng/ml at pretreatment, 10.4 +/- 1.0 ng/ml at post-treatment and 17.3 +/- 1.9 ng/ml at recurrence. The positive rates were 69.2% at pre-treatment, 0% at post-treatment and 100% at recurrence. In relation of histology, the positive rates were particularly high in patients with serious cystadenocarcinoma and embryonal carcinoma. In conclusion, P-III-P in sera was very useful as tumor marker in diagnosis of malignant ovarian tumors, while it was not aided to detect the early cancers.
研究了血清中III型前胶原肽（P-III-P）作为肿瘤标志物在卵巢肿瘤患者中的应用价值。采用放射免疫法测定血清中P-III-P的浓度。72名健康女性作为对照，其P-III-P的平均值为8.5±2.7 ng/ml。因此，临界值（平均值+2倍标准差）设定为13.9 ng/ml。健康对照的阳性率为4.2%。良性卵巢肿瘤患者的P-III-P平均值为8.7±2.3 ng/ml，阳性率为0%。交界性恶性卵巢肿瘤患者的P-III-P平均值为8.0±1.5 ng/ml，阳性率为0%。在良性和交界性恶性病例中，TPA、IAP、CA-125和CA 19-9等肿瘤标志物的假阳性率相对较高。恶性卵巢肿瘤患者治疗前P-III-P平均值为19.7±9.9 ng/ml，治疗后为10.4±1.0 ng/ml，复发时为17.3±1.9 ng/ml。治疗前阳性率为69.2%，治疗后为0%，复发时为100%。在组织学方面，浆液性囊腺癌和胚胎癌患者的阳性率特别高。总之，血清中的P-III-P作为恶性卵巢肿瘤诊断的肿瘤标志物非常有用，但对早期癌症的检测没有帮助。
