Comet M
Service de Biophysique et Médecine Nucléaire, Centre Hospitalier Régional, La Tronche.
J Mal Vasc. 1989;14(3):226-30.
Screening for abnormal capillary filtration in the limbs with radioactive tracers requires the use of molecules of a known hydrodynamic radius. The molecule labeling should be obtained with a pure gamma-emitting radioactive atom, presenting a steady bond with the molecule, in vivo. Indium-111-labeled albumin appears to be the best tracer, and should be injected concurrently with the technetium 99m-labeled erythrocytes. The latter tracer permits assessing volume variations induced by the venous blood return block needed to obtain a capillary pressure increase. A qualitative estimation of lymphatic flow, and screening for abnormal permeability of the lymphatic vessels must be carried out as part of any capillary filtration study protocol.
使用放射性示踪剂筛查四肢毛细血管滤过异常需要使用具有已知流体动力学半径的分子。分子标记应由纯γ发射放射性原子获得，该原子在体内与分子形成稳定键。铟-111标记的白蛋白似乎是最佳示踪剂，应与锝99m标记的红细胞同时注射。后一种示踪剂可用于评估为使毛细血管压力升高而进行的静脉血回流阻断所引起的容积变化。作为任何毛细血管滤过研究方案的一部分，必须对淋巴流量进行定性评估，并筛查淋巴管的异常通透性。
