Karakitsios Ioannis, Joy Joyce, Mihcin Senay, Melzer Andreas
a Institute of Medical Science and Technology , University of Dundee , Dundee , UK.
Minim Invasive Ther Allied Technol. 2017 Apr;26(2):92-96. doi: 10.1080/13645706.2016.1253589. Epub 2016 Nov 15.
The purpose of this work was to measure the essential acoustic parameters, i.e., acoustic impedance, reflection coefficient, attenuation coefficient, of Thiel embalmed human and animal liver. The Thiel embalmed tissue can be a promising, pre-clinical model to study liver treatment with Magnetic Resonance-guided Focused Ultrasound (MRgFUS).
Using a single-element transducer and the contact pulse-echo method, the acoustic parameters, i.e., acoustic impedance, reflection coefficient and attenuation coefficient of Thiel embalmed human and animal liver were measured.
The Thiel embalmed livers had higher impedance, similar reflection and lower attenuation compared to the fresh tissue.
Embalming liver with Thiel fluid affects its acoustic properties. During MRgFUS sonication of a Thiel organ, more focused ultrasound (FUS) will be backscattered by the organ, and higher acoustic powers are required to reach coagulation levels (temperatures >56 °C).
本研究旨在测量经蒂尔（Thiel）防腐处理的人体及动物肝脏的基本声学参数，即声阻抗、反射系数和衰减系数。经蒂尔防腐处理的组织可能是一种很有前景的临床前模型，用于研究磁共振引导聚焦超声（MRgFUS）肝脏治疗。
使用单元素换能器和接触脉冲回波法，测量经蒂尔防腐处理的人体及动物肝脏的声学参数，即声阻抗、反射系数和衰减系数。
与新鲜组织相比，经蒂尔防腐处理的肝脏具有更高的阻抗、相似的反射和更低的衰减。
用蒂尔液对肝脏进行防腐处理会影响其声学特性。在对经蒂尔处理的器官进行MRgFUS超声处理时，器官会反向散射更多的聚焦超声（FUS），并且需要更高的声功率才能达到凝固水平（温度>56°C）。
