Wikstrand John, Herlitz Hans, Berglund Göran
a Department of Clinical Physiology, Hpertension Unit and From the Department of Nephrology, Sahlgrensku Sjukhuset , University of Göteborg , S-413 45 Göteborg , Sweden.
Scand J Urol Nephrol. 1984 Jul;18(sup79):81-85. doi: 10.1080/00365599.1984.11783721.
After a run-in period on placebo, 15 patients with primary hypertension got antihypertensive treatment with enalapril single therapy during six weeks. Before and four hours after drug administration simultaneous non-invasive recordings of ECG, phonocardiogram and carotid pulse tracing or apexcardio-gram or impedance cardiogram were made. After six weeks' therapy the recordings were repeated 12 hours and four hours after dose intake. The results showed enalapril to be a potent antihypertensive agent with considerable effect already four hours after the first dose intake. The blood pressure reduction was explained by a decrease in total peripheral resistance, semiquantitatively measured with impedance cardiography. Cardiac output was significantly higher during long-term treatment than betore therapy started, due to a significant increase in stroke volume. Lef ventricular (LV) diastolic function was not altered but a considerable improvement in LV systolic function was achieved as judged from the systolic time intervals. Open questioning regarding side effects indicated good tolerance.
在接受安慰剂导入期治疗后，15例原发性高血压患者接受了为期六周的依那普利单药降压治疗。在给药前及给药后4小时，同步进行心电图、心音图以及颈动脉脉搏描记图或心尖心动图或阻抗心动图的无创记录。六周治疗后，在给药后12小时和4小时重复进行记录。结果显示，依那普利是一种强效降压药，首次给药后4小时即有显著效果。血压降低是由于总外周阻力降低所致，外周阻力通过阻抗心动图进行半定量测量。长期治疗期间的心输出量显著高于治疗开始前，这是由于每搏输出量显著增加。左心室（LV）舒张功能未改变，但从收缩时间间期判断，左心室收缩功能有显著改善。关于副作用的开放式询问表明耐受性良好。
