Taylor Stephanie D, Everett Sharlette V, Taylor Thomas N, Watson Douglas J, Taylor-Stokes Gavin
Global Health Outcomes, Merck Sharp and Dohme Corp, Whitehouse Station, NJ, USA.
Pharmacy Practice, Wayne State University, Detroit, MI, USA.
Open Access Rheumatol. 2013 Jul 29;5:69-76. doi: 10.2147/OARRR.S41940. eCollection 2013.
The clinical response to traditional nonsteroidal anti-inflammatory drugs (tNSAIDs) varies substantially. The objective of this study was to describe physicians' and patients' perceptions of response to tNSAIDs as measured by satisfaction with control of patients' osteoarthritis (OA).
A cross-sectional survey was undertaken in 2009 in Germany, Spain, and the UK. Linked physician and patient questionnaires collected data on OA management, degree of pain and disability, and satisfaction with OA control.
The study included 363 treating physicians and 713 patients receiving tNSAIDs. Patient mean (standard deviation) age was 65.5 (11.0) years (range 36-94 years); 60% were women; 86% were white; and one-quarter were obese. Dissatisfaction with control of patients' OA was expressed by physicians or their patients, or both, for 51% of patients, including 208 patients (31%) with mild OA and 478 patients (60%) with moderate or severe OA. Overall, 37% of patients reported dissatisfaction and 34% had a physician who reported dissatisfaction. Patient and physician assessments were the same in 70% of cases; Cohen's κ coefficient was 0.34 (95% confidence interval 0.26-0.41), indicating fair agreement. Of those reporting dissatisfaction, most physicians (79%) and patients (64%) believed that the current control was the best that could be achieved. The most common reasons for which physicians reported dissatisfaction were inadequate response (56%), side effects (11.1%), and poor tolerance (7.8%).
One-half of patients or their treating physicians were dissatisfied with the control of OA provided by tNSAID therapy; moreover, most believed it was the best control that could be achieved.
对传统非甾体抗炎药（tNSAIDs）的临床反应差异很大。本研究的目的是描述医生和患者对tNSAIDs反应的看法，以患者骨关节炎（OA）控制的满意度来衡量。
2009年在德国、西班牙和英国进行了一项横断面调查。将医生问卷和患者问卷相结合，收集了有关OA管理、疼痛和残疾程度以及对OA控制满意度的数据。
该研究纳入了363名治疗医生和713名接受tNSAIDs治疗的患者。患者的平均（标准差）年龄为65.5（11.0）岁（范围36 - 94岁）；60%为女性；86%为白人；四分之一为肥胖者。51%的患者，包括208名轻度OA患者（31%）和478名中度或重度OA患者（60%），医生或患者或两者都对患者OA的控制表示不满。总体而言，37%的患者报告不满，34%的患者的医生报告不满。70%的病例中患者和医生的评估一致；科恩κ系数为0.34（95%置信区间0.26 - 0.41），表明一致性尚可。在报告不满的人中，大多数医生（79%）和患者（64%）认为目前的控制是所能达到的最佳效果。医生报告不满的最常见原因是反应不足（56%）、副作用（11.1%）和耐受性差（7.8%）。
一半的患者或其治疗医生对tNSAID治疗提供的OA控制不满意；此外，大多数人认为这是所能达到的最佳控制。
