Department of Psychiatry, University of Naples SUN, Naples, Italy.
Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', Section of Neurosciences, University of Salerno, Salerno, Italy.
Eur Eat Disord Rev. 2017 Jan;25(1):13-18. doi: 10.1002/erv.2485. Epub 2016 Oct 27.
Malnutrition and childhood trauma were shown to affect in opposite way the cortisol awakening response (CAR) of patients with anorexia nervosa (AN). To assess the influence of binge-purging behaviour on the CAR of AN patients, we measured the CAR of restrictive AN (ANR) or binge-purging AN (ANBP) patients without history of childhood maltreatment. Seventeen ANBP women, 18 ANR women and 42 healthy women collected saliva samples at awakening and after 15, 30 and 60 min, and filled in the Eating Disorder Inventory-2 (EDI-2). ANR and ANBP patients exhibited a CAR significantly higher than healthy women. Moreover, the CAR of ANBP women was even higher than that of ANR women and positively correlated with the bulimia subitem scores of the EDI-2. Present findings show, for the first time, differences in the CAR between ANBP and ANR subtypes, which may suggest a possible connection between the HPA axis functioning and binge-purging. Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association.
营养不良和儿童创伤以相反的方式影响神经性厌食症（AN）患者的皮质醇觉醒反应（CAR）。为了评估暴饮暴食行为对 AN 患者 CAR 的影响，我们测量了无儿童期虐待史的限制型 AN（ANR）或暴食-清除型 AN（ANBP）患者的 CAR。17 名 ANBP 女性、18 名 ANR 女性和 42 名健康女性在觉醒时和 15、30 和 60 分钟后采集唾液样本，并填写饮食失调量表-2（EDI-2）。ANR 和 ANBP 患者的 CAR 明显高于健康女性。此外，ANBP 女性的 CAR 甚至高于 ANR 女性，且与 EDI-2 的暴食分量表得分呈正相关。本研究首次显示了 ANBP 和 ANR 亚型之间 CAR 的差异，这可能表明 HPA 轴功能与暴食-清除之间存在某种联系。版权所有 © 2016 约翰威立父子有限公司和饮食失调协会。
