Zaĭtsev A V, Rozenshtraukh L V, Fast V G, Bobrovskiĭ R V, Pertsov A M
Kardiologiia. 1989 Jun;29(6):80-5.
The authors examined tachycardias induced by administering acetylcholine (AC), 1-2 micrograms into the artery of sinus node (ASN) of an isolated specimen of the canine right atrium, which had spontaneous automatism. Bilateral multielectrode mapping was employed. The episodes of tachycardia occurred during AC-induced arrest of sinus rhythm. In 81% of the cases, episodes of arrhythmia consisted of 2-3 beats, in 19%, 6-150 beats. The mapping revealed a focal picture of activation during short-term episodes of arrhythmia and transition from a focal type of activation to the re-entry in most cases of "prolonged" episodes. With this, excitation circulation might be detected only on one side of the specimen, in the presence of the focal activation picture, on the other. Focus-re-entry transition is proposed to be caused by a mechanism associated with heterogeneous refractoriness of atrial tissue.
作者通过向具有自发自律性的犬右心房离体标本的窦房结动脉（ASN）内注入1 - 2微克乙酰胆碱（AC）来诱发心动过速，并采用双侧多电极标测法。心动过速发作发生在AC诱导的窦性节律停搏期间。81%的病例中，心律失常发作由2 - 3次搏动组成，19%的病例中，发作由6 - 150次搏动组成。标测显示，在心律失常短期发作期间呈现局灶性激动图像，而在大多数“延长”发作的病例中，激动类型从局灶性转变为折返性。据此，在标本一侧存在局灶性激动图像的情况下，仅在另一侧可能检测到激动循环。局灶 - 折返转变被认为是由与心房组织复极不一致相关的机制引起的。
