Ali Hasan, Singh Sandeep Kumar
Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Ranchi- 835 215, Jharkhand, India.
Ther Deliv. 2016 Oct;7(10):691-709. doi: 10.4155/tde-2016-0038.
This review projects the prospects and issues faced by solid lipid nanoparticles (SLNs) in current scenarios, specially related to its clinical implementation and effectiveness. We re-examine the basic concept of biobehavior and movement of SLNs as a nanomedicine carrier. The extensive survey of the uptake and absorption mechanism from different routes, distribution pattern, targeting efficiency, effect of surface functionalization on biodistribution, elimination pathways and toxic effects have been documented. In general, the objective of this review is to boost our knowledge about the interaction of SLNs with the bioenvironment, their movement in, and effect on, a living system and future prospects.
本综述预测了固体脂质纳米粒（SLNs）在当前情况下所面临的前景和问题，特别是与其临床应用和有效性相关的方面。我们重新审视了SLNs作为一种纳米药物载体的生物行为和移动的基本概念。已记录了对不同给药途径的摄取和吸收机制、分布模式、靶向效率、表面功能化对生物分布的影响、消除途径和毒性作用的广泛研究。总体而言，本综述的目的是增进我们对SLNs与生物环境相互作用、它们在活体系统中的移动和影响以及未来前景的了解。
