Hadjilaskari P, Fengler R, Hartmann R, Henze G
Universitäts-Kinderklinik Berlin.
Klin Padiatr. 1989 Jul-Aug;201(4):316-21. doi: 10.1055/s-2008-1026721.
Ten out of 20 children with malignant diseases who received cisplatin in combination with other drugs developed hearing impairment primarily at the higher and rarely also at the lower frequencies. The CDDP-ototoxicity was found to be dose-related and irreversible. Audiometric abnormalities were symmetrical and bilateral. Two patients had symptomatic hearing impairment. Ototoxicity was more severe with higher individual and higher cumulative doses. CNS-irradiation increases the ototoxic effect of CDDP. Audiometric testing at the beginning of chemotherapy and during chemotherapy is important to find out preexisting disturbances of hearing function and to recognize early developing hearing loss.
20名接受顺铂与其他药物联合治疗的恶性疾病患儿中，有10名主要在高频出现听力障碍，低频也很少出现。发现顺铂耳毒性与剂量相关且不可逆。听力测定异常是对称且双侧的。两名患者有症状性听力障碍。个体剂量和累积剂量越高，耳毒性越严重。中枢神经系统放疗会增加顺铂的耳毒性作用。化疗开始时和化疗期间进行听力测定很重要，以便发现预先存在的听力功能障碍并识别早期出现的听力损失。
