Wang Tianzhen, He Yan, Zhu Yuanyuan, Chen Mingwei, Weng Mingjiao, Yang Chao, Zhang Yan, Ning Ning, Zhao Ran, Yang Weiwei, Jin Yinji, Li Jing, Redpath Riju James Rajkumar Ezakiel, Zhang Lei, Jin Xiaoming, Zhong Zhaohua, Zhang Fengmin, Wei Yunwei, Shen Guomin, Wang Dong, Liu Ying, Wang Guangyu, Li Xiaobo
Department of Pathology, Harbin Medical University, Harbin, China.
Department of Gastrointestinal Medical Oncology, the Affiliated Tumor Hospital of Harbin Medical University, Harbin, China.
Oncotarget. 2016 Nov 29;7(48):79605-79616. doi: 10.18632/oncotarget.12869.
Lin28A and Lin28B are highly conserved RNA binding proteins with similar structure and functions. Recent studies demonstrated that both of them act as oncogenes and promote cancer progression. However, few researches compared the expression and functions of both oncogenes in human malignant tumors at same time. Additionally, although the expression and role of Lin28B in colon cancer is frequently reported, the expression and functions of Lin28A in colon cancer are largely unknown. In this study, we have systematically evaluated the expressional pattern, mutation status and correlation of both Lin28A and Lin28B in colon cancer tissues for the first time, and compared the roles of Lin28A and Lin28B in the proliferation, migration, invasion and apoptosis of colon cancer cells in vitro. We have showed that they are co-expressed and have functional similarities, however, the molecular mechanisms underlying their similar functions may not be identical. This study contributes to clarify the similarities and differences of Lin28A and Lin28B in colon cancer progression.
Lin28A和Lin28B是结构和功能相似的高度保守的RNA结合蛋白。最近的研究表明，它们均作为癌基因发挥作用并促进癌症进展。然而，很少有研究同时比较这两种癌基因在人类恶性肿瘤中的表达和功能。此外，尽管Lin28B在结肠癌中的表达和作用经常被报道，但Lin28A在结肠癌中的表达和功能在很大程度上尚不清楚。在本研究中，我们首次系统评估了Lin28A和Lin28B在结肠癌组织中的表达模式、突变状态及相关性，并比较了Lin28A和Lin28B在体外对结肠癌细胞增殖、迁移、侵袭和凋亡的作用。我们发现它们共同表达且具有功能相似性，然而，其相似功能背后的分子机制可能并不相同。本研究有助于阐明Lin28A和Lin28B在结肠癌进展中的异同。
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