Zuo Tian, Liu Xuehui, Jiang Lu, Mao Shuai, Yin Xin, Guo Liheng
The Second Clinical College of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510120, People's Republic of China.
Department of Critical Care Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510120, People's Republic of China.
BMC Cardiovasc Disord. 2016 Oct 28;16(1):207. doi: 10.1186/s12872-016-0379-z.
Hyperuricemia may be associated with an increased risk of coronary heart disease (CHD) mortality; however, the results from prospective studies are conflicting. The objective of this study was to assess the association between hyperuricemia and risk of CHD mortality by performing a meta-analysis.
Pubmed and Embase were searched for relevant prospective cohort studies published until July 2015. Studies were included only if they reported data on CHD mortality related to hyperuricemia in a general population. The pooled adjusted relative risk (RR) was calculated using a random-effects model.
A total of 14 studies involving 341 389 adults were identified. Hyperuricemia was associated with an increased risk of CHD mortality (RR: 1.14; 95 % CI: 1.06-1.23) and all-cause mortality (RR: 1.20; 95 % CI: 1.13-1.28). For each increase of 1 mg/dl of serum uric acid (SUA), the overall risks of CHD and all-cause mortality increased by 20 and 9 %, respectively. According to the gender subgroup analyses, hyperuricemia increased the risk of CHD mortality in women (RR: 1.47; 95 % CI: 1.21-1.73) compared to men (RR: 1.10; 95 % CI: 1.00-1.19). The risk of all-cause mortality was greater in women.
Hyperuricemia may modestly increase the risk of CHD and all-cause mortality. Future research is needed to determine whether urate-lowering therapy has beneficial effects for reducing CHD mortality.
高尿酸血症可能与冠心病（CHD）死亡率增加有关；然而，前瞻性研究的结果存在冲突。本研究的目的是通过进行荟萃分析来评估高尿酸血症与CHD死亡风险之间的关联。
检索了截至2015年7月发表的有关前瞻性队列研究的PubMed和Embase数据库。仅纳入那些报告了普通人群中与高尿酸血症相关的CHD死亡率数据的研究。采用随机效应模型计算合并调整相对风险（RR）。
共纳入14项涉及341389名成年人的研究。高尿酸血症与CHD死亡率增加（RR：1.14；95%CI：1.06 - 1.23）和全因死亡率增加（RR：1.20；95%CI：1.13 - 1.28）相关。血清尿酸（SUA）每升高1mg/dl，CHD和全因死亡率的总体风险分别增加20%和9%。根据性别亚组分析，与男性（RR：1.10；95%CI：1.00 - 1.19）相比，高尿酸血症增加了女性CHD死亡风险（RR：1.47；95%CI：1.21 - 1.73）。女性的全因死亡风险更高。
高尿酸血症可能适度增加CHD和全因死亡风险。需要进一步研究以确定降尿酸治疗是否对降低CHD死亡率有有益作用。
