Barb C R, Kineman R D, Kesner J S, Rampacek G B, Kraeling R R
USDA-ARS, Richard B. Russell Agricultural Research Center, Athens, GA 30613.
Life Sci. 1989;45(8):691-6. doi: 10.1016/0024-3205(89)90087-8.
Antagonism of endogenous opioids with naloxone stimulates luteinizing hormone (LH) release in mature but not prepuberal gilts. The present report demonstrates that the opiate agonist morphine (500 micrograms), administered intracerebroventricularly (ICV), reduced LH secretion in both ovariectomized mature and prepuberal gilts. We suggest that opioid receptors are functionally coupled to the GnRH secretory system in prepuberal gilts even though endogenous opioid peptide modulation of LH secretion was not demonstrable in our previous studies.
用纳洛酮拮抗内源性阿片类物质可刺激成熟母猪而非青春期前小母猪释放促黄体生成素（LH）。本报告表明，经脑室内（ICV）注射阿片类激动剂吗啡（500微克）可降低去卵巢成熟母猪和青春期前小母猪的LH分泌。我们认为，尽管在我们之前的研究中未证实内源性阿片肽对LH分泌的调节作用，但阿片受体在功能上与青春期前小母猪的GnRH分泌系统相关联。
