Wang Sheng-Fang, Wu Ming-Yue, Cai Cui-Zan, Li Min, Lu Jia-Hong
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau.
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong.
J Ethnopharmacol. 2016 Dec 24;194:861-876. doi: 10.1016/j.jep.2016.10.069. Epub 2016 Oct 26.
Traditional Chinese medicine (TCM), an ancient yet still alive medicinal system widely used in East Asia, has played an essential role in health maintenance and diseases control, for a wide range of human chronic diseases like cancers and neurodegenerative diseases. TCM-derived compounds and extracts attract wide attention for their potential application as therapeutic agents against above mentioned diseases.
Recent years the enthusiasm in searching for autophagy regulators for human diseases has yielded many positive hits. TCM-derived compounds as important sources for drug discovery have been widely tested in different models for autophagy modulation. Here we summarize the current progress in the discovery of natural autophagy regulators from TCM for the therapeutic application in cancer and neurodegenerative disease models, aiming to provide the direct link from traditional use to new pharmacological application.
The present review collected the literature published during the recent 10 years which studied the effect of TCM-derived compounds or extracts on autophagy regulation from PubMed, Web of Science, Google Scholar and Science Direct. The names of chemical compounds studied in this article are corresponding to the information in journal plant list.
In this review, we give a brief introduction about the autophagy and its roles in cancer and neurodegenerative disease models and describe the molecular mechanisms of autophagy modulation. We also make comprehensive lists to summarize the effects and underlying mechanisms of TCM-derived autophagy regulators in cancer and neurodegenerative disease models. In the end of the review, we discuss the current strategies, problems and future direction for TCM-derived autophagy regulators in the treatment of human diseases.
A number of data from in vivo and in vitro models indicated TCM derived compounds and extracts hold great potential for the treatment of human diseases including cancers and neurodegenerative diseases. Autophagy, as a novel and promising drug target involved in a wide range of human diseases, can be modulated by many TCM derived agents, indicating autophagy modulation may be an important mechanism underlying the therapeutic effect of TCM in treating diseases. Furthermore, we look forward to seeing the discovery of ideal autophagy modulators from TCM with considerably higher selectivity for the treatment of human diseases.
传统中医（TCM）是一种古老但仍在使用的医学体系，在东亚广泛应用，在维持健康和控制疾病方面发挥了重要作用，适用于多种人类慢性疾病，如癌症和神经退行性疾病。源自传统中医的化合物和提取物因其作为上述疾病治疗药物的潜在应用而备受关注。
近年来，寻找人类疾病自噬调节剂的热情取得了许多积极成果。源自传统中医的化合物作为药物发现的重要来源，已在不同的自噬调节模型中进行了广泛测试。在此，我们总结了从传统中医中发现天然自噬调节剂用于癌症和神经退行性疾病模型治疗应用的当前进展，旨在提供从传统用途到新药理学应用的直接联系。
本综述收集了最近10年在PubMed、科学网、谷歌学术和科学Direct上发表的研究源自传统中医的化合物或提取物对自噬调节作用的文献。本文研究的化合物名称与期刊植物名录中的信息相对应。
在本综述中，我们简要介绍了自噬及其在癌症和神经退行性疾病模型中的作用，并描述了自噬调节的分子机制。我们还制作了综合列表，总结了源自传统中医的自噬调节剂在癌症和神经退行性疾病模型中的作用及潜在机制。在综述结尾，我们讨论了源自传统中医的自噬调节剂在治疗人类疾病方面的当前策略、问题和未来方向。
来自体内和体外模型的大量数据表明，源自传统中医的化合物和提取物在治疗包括癌症和神经退行性疾病在内的人类疾病方面具有巨大潜力。自噬作为一种涉及多种人类疾病的新型且有前景的药物靶点，可被许多源自传统中医的药物调节，这表明自噬调节可能是传统中医治疗疾病疗效的重要机制。此外，我们期待从传统中医中发现对治疗人类疾病具有更高选择性的理想自噬调节剂。
