科科韦拉病毒的系统发育和进化史。
The phylogenetic and evolutionary history of Kokobera virus.
作者信息
Blasi Aletheia, Lo Presti Alessandra, Cella Eleonora, Angeletti Silvia, Ciccozzi Massimo
机构信息
Unit of Clinical Pathology and Microbiology, University Campus Bio-Medico of Rome, Italy.
Department of Infectious Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, Rome, Italy.
出版信息
Asian Pac J Trop Med. 2016 Oct;9(10):968-972. doi: 10.1016/j.apjtm.2016.07.028. Epub 2016 Aug 10.
OBJECTIVE
To estimate the genetic diversity of Kokobera virus, the date of origin and the spread among different viruses in the endemic regions of Australia.
METHODS
Two datasets were built. The first consisting of 29 sequences of the NS5/3' UTR region of Kokobera group downloaded from GenBank, the second including only 24 sequences of Kokobera viruses, focus is on this group.
RESULTS
Bayesian time analysis revealed two different entries in Australia of Kokobera virus in the 50s years with the dated ancestor in 1861 year. Clades A and B showed a clear separation of the Kokobera sequences according to the geographic region.
CONCLUSIONS
Data from the study showed as Kokobera virus, despite of its ancient origin and its circulation before the European colonization, remained limited to the Australian country and nowadays limited mostly to the regions were Australian marsupials are mostly found.
目的
评估科科贝拉病毒的遗传多样性、起源时间以及在澳大利亚流行地区不同病毒间的传播情况。
方法
构建了两个数据集。第一个数据集由从GenBank下载的科科贝拉病毒组NS5/3'UTR区域的29个序列组成，第二个数据集仅包含24个科科贝拉病毒序列，重点关注该病毒组。
结果
贝叶斯时间分析显示，20世纪50年代科科贝拉病毒在澳大利亚有两次不同的传入，其祖先可追溯到1861年。进化枝A和B根据地理区域显示了科科贝拉病毒序列的明显分离。
结论
研究数据表明，尽管科科贝拉病毒起源古老且在欧洲殖民之前就已传播，但仍局限于澳大利亚，如今大多局限于澳大利亚有袋动物最常见的地区。
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