a Biosciences Laboratory , Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS , Meldola , Italy.
b Department of Medical Oncology , Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS , Meldola , Italy.
Expert Rev Mol Diagn. 2016 Dec;16(12):1283-1290. doi: 10.1080/14737159.2016.1254551. Epub 2016 Nov 10.
Although the role of circulating cell free DNA in cancer has been widely demonstrated, less is known about the role of urine cell free DNA (UcfDNA). UcfDNA can serve as a 'liquid biopsy' for urological and non-urological tumors, as it carries information on DNA from cells exfoliated in urine and from circulation. Areas covered: We review the studies on UcfDNA as a source of biomarkers for cancer, focusing on the new techniques and the differences between urological and non-urological tumors. We searched Pubmed for articles published between 1998 and 2016 with the following key words and phrases: 'urine' and 'cell free DNA' or 'liquid biopsy' or 'cancer'. Expert commentary: Despite the few papers published on this topic, UcfDNA is an important component of 'liquid biopsy', a useful and non-invasive tool for cancer diagnosis, prognosis and treatment monitoring, containing a wide range of genetic information.
虽然循环游离 DNA 在癌症中的作用已得到广泛证实，但关于尿游离 DNA（UcfDNA）的作用知之甚少。UcfDNA 可以作为尿和循环中脱落细胞的 DNA 信息载体，作为泌尿系统和非泌尿系统肿瘤的“液体活检”。
我们综述了 UcfDNA 作为癌症生物标志物来源的研究，重点介绍了新技术以及泌尿系统和非泌尿系统肿瘤之间的差异。我们在 Pubmed 上检索了 1998 年至 2016 年间发表的以下关键词和短语的文章：“urine”和“cell free DNA”或“liquid biopsy”或“cancer”。
尽管关于这个主题的论文很少，但 UcfDNA 是“液体活检”的重要组成部分，是一种用于癌症诊断、预后和治疗监测的有用且非侵入性工具，包含广泛的遗传信息。
