发作性偏头痛患者T2加权成像上的非特异性导水管周围灰质病变
Nonspecific periaqueductal gray lesions on T2WI in episodic migraine.
作者信息
Chen Zhiye, Chen Xiaoyan, Liu Mengqi, Liu Shuangfeng, Ma Lin, Yu Shengyuan
机构信息
Department of Radiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
Department of Neurology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.
出版信息
J Headache Pain. 2016 Dec;17(1):101. doi: 10.1186/s10194-016-0695-9. Epub 2016 Oct 28.
BACKGROUND
The specific periaqueductal gray (PAG) lesions with migraine-like headache were easily identified on conventional MR images in clinical practice, and the aim of this study is to investigate the nonspecific periaqueductal gray (PAG) lesions in episodic migraine (EM) patients based on T2 weighted imaging (T2WI).
METHODS
T2WI images were obtained from 18 EM patients and 18 normal controls (NC) on 3.0 T MR system. The images were observed by two experienced radiologists, and the lesions were identified on T2WI by consensus by 2 experienced neuroradiologists blinded to the patient identity. Chi-Square test was performed for the significance test.
RESULTS
Ring-like hyperintensity lesions (HILs) around the PAG region were observed in 14 EM patients and in 5 NCs on T2WI. Four EM patients and 13 NCs were normal in PAG region. The significance was revealed by Chi-Square test (P = 0.003).
CONCLUSION
HIL of PAG may be the direct evidence of the EM genesis, and the further structural and functional study should be performed to elucidate the neuromechanism of migraine pathogenesis.
背景
在临床实践中，常规磁共振成像（MR）图像上容易识别出伴有偏头痛样头痛的特定导水管周围灰质（PAG）病变，本研究旨在基于T2加权成像（T2WI）研究发作性偏头痛（EM）患者的非特异性导水管周围灰质（PAG）病变。
方法
在3.0 T MR系统上获取18例EM患者和18例正常对照（NC）的T2WI图像。由两名经验丰富的放射科医生观察图像，两名对患者身份不知情的经验丰富的神经放射科医生通过共识在T2WI上识别病变。进行卡方检验以进行显著性检验。
结果
在T2WI上，14例EM患者和5例NC患者的PAG区域周围观察到环状高信号病变（HILs）。4例EM患者和13例NC患者的PAG区域正常。卡方检验显示差异具有显著性（P = 0.003）。
结论
PAG的HIL可能是EM发病的直接证据，应进一步进行结构和功能研究以阐明偏头痛发病机制的神经机制。
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