Chen Zhiye, Chen Xiaoyan, Liu Mengqi, Liu Shuangfeng, Shu Siyun, Ma Lin, Yu Shengyuan
Department of Radiology, Chinese PLA General Hospital, Beijing, 100853, China.
Department of Neurology, Chinese PLA General Hospital, Beijing, 100853, China.
J Headache Pain. 2016 Dec;17(1):89. doi: 10.1186/s10194-016-0682-1. Epub 2016 Sep 26.
The marginal division of neostriatum (MrD) is a flat, pan-shaped zone between the neostriatum and the globus pallidus, and previous documents demonstrated that it was involved in the modulation of pain. The aim of this study is to investigate the roles of the MrD of the human brain in the chronicization migraine using resting state functional magnetic resonance imaging (rs-fMRI).
Conventional MRI, 3D structure images, and rs-fMRI were performed in 18 patients with episodic migraines (EM), 16 patients with chronic migraine (CM), 44 patients with medication overuse headache plus chronic migraine (MOH + CM), and 32 normal controls (NC). MrD was defined using manual delineation on structural images, and was selected as the seed to calculate the functional connectivity (FC).
Compared with the NC group, the decreased FC of MrD was observed in the EM and CM groups, and increased FC of MrD was demonstrated in all patient groups. Compared with the EM group, the decreased FC of MrD was revealed in the CM and MOH + CM groups, and the increased FC occurred only in the CM group. Increased FC of MrD alone was observed in the MOH + CM group compared with that in the CM group.
This study confirmed the double neuromodulation network of MrD in pain modulation and migraine chronicization; however, the mechanism requires further investigation.
新纹状体边缘区（MrD）是位于新纹状体和苍白球之间的一个扁平的盘状区域，既往文献表明其参与疼痛调节。本研究旨在使用静息态功能磁共振成像（rs-fMRI）探讨人脑MrD在偏头痛慢性化中的作用。
对18例发作性偏头痛（EM）患者、16例慢性偏头痛（CM）患者、44例药物过量使用性头痛合并慢性偏头痛（MOH+CM）患者和32名正常对照（NC）进行常规MRI、三维结构成像和rs-fMRI检查。通过在结构图像上手动勾勒来定义MrD，并将其作为种子点来计算功能连接（FC）。
与NC组相比，EM组和CM组中观察到MrD的FC降低，所有患者组中MrD的FC均升高。与EM组相比，CM组和MOH+CM组中MrD的FC降低，且仅CM组中FC升高。与CM组相比，MOH+CM组中仅观察到MrD的FC升高。
本研究证实了MrD在疼痛调节和偏头痛慢性化中的双重神经调节网络；然而，其机制仍需进一步研究。
