Chen Shuang, Guo Xiaofan, Dong Siyuan, Li Zhao, Sun Yingxian
a Department of Cardiology , The First Affiliated Hospital of China Medical University , Shenyang , P.R. China.
b Department of Thoracic Surgery , The First Affiliated Hospital of China Medical University , Shenyang , P.R. China.
Postgrad Med. 2017 Mar;129(2):216-223. doi: 10.1080/00325481.2017.1255126. Epub 2016 Nov 18.
Hyperhomocysteinemia (Hhcy) is a known cardiovascular disease (CVD) risk factor. Observational studies had supported the role of lifestyle factors such as physical activity, diet and alcohol consumption in CVD prevention. Our study aimed to determine the relationship between Hhcy and lifestyle factors in general Chinese population.
In this cross-sectional study, a total of 7135 adults (3320 men and 3815 women) aged 35 years or older were recruited from the rural Northeast China. Data on lifestyle factors, such as physical activities, sleep duration, current smoking and drinking status, dietary habits and familial factors were collected in interviews and laboratory examinations were performed by well-trained personnel.
Plasma total homocysteine (tHcy) level was higher in men than in women, and greater in the elderly than in other age groups. Subjects with Hhcy were more likely to be current smokers (men: OR 1.328, 95% CI 1.143-1.543, p<0.001; women: OR 1.465, 95% CI 1.214-1.767, p<0.001). Separately, men with Hhcy were more likely to have an education of primary school or below (OR 1.251, 95% CI 1.068-1.465, p=0.006) and less likely to eat more vegetables (OR 0.927, 95% CI 0.863-0.996, p=0.037) than the normal-tHcy participants. In women, participants with Hhcy were more likely to have longer sleeping time (>9h/d) (OR 1.677, 95% CI 1.292-2.177, p<0.001), low physical activity (OR 1.721, 95% CI 1.197-2.475, p=0.044) and increased diet score (OR 1.126, 95% CI 1.007-1.259, p=0.037) and less likely to be current drinkers (OR 0.488, 95% CI 0.297-0.802, p=0.005) than the normal-tHcy participants.
Our study revealed that physical activity and current drinking status were not significantly associated with Hhcy in males, but inversely associated in females. In both genders, current smoking status and dietary habits were significantly associated with Hhcy. Our study supports existing recommendations for Chinese to maintain a physically active behaviors and healthy lifestyle habits.
高同型半胱氨酸血症（Hhcy）是已知的心血管疾病（CVD）危险因素。观察性研究支持身体活动、饮食和饮酒等生活方式因素在预防CVD中的作用。我们的研究旨在确定中国普通人群中Hhcy与生活方式因素之间的关系。
在这项横断面研究中，从中国东北农村地区招募了7135名35岁及以上的成年人（3320名男性和3815名女性）。通过访谈收集了身体活动、睡眠时间、当前吸烟和饮酒状况、饮食习惯和家族因素等生活方式因素的数据，并由训练有素的人员进行实验室检查。
男性血浆总同型半胱氨酸（tHcy）水平高于女性，老年人高于其他年龄组。Hhcy患者更有可能是当前吸烟者（男性：OR 1.328，95%CI 1.143 - 1.543，p<0.001；女性：OR 1.465，95%CI 1.214 - 1.767，p<0.001）。单独来看，与正常tHcy参与者相比，患有Hhcy的男性受小学及以下教育的可能性更大（OR 1.251，95%CI 1.068 - 1.465，p = 0.006），吃较多蔬菜的可能性较小（OR 0.927，95%CI 0.863 - 0.996，p = 0.037）。在女性中，与正常tHcy参与者相比，患有Hhcy的参与者睡眠时间较长（>9小时/天）的可能性更大（OR 1.677，95%CI 1.292 - 2.177，p<0.001），身体活动较少（OR 1.721，95%CI 1.197 - 2.475，p = 0.044），饮食得分较高（OR 1.126，95%CI 1.007 - 1.259，p = 0.037），当前饮酒的可能性较小（OR 0.488，95%CI 0.297 - 0.802，p = 0.005）。
我们的研究表明，身体活动和当前饮酒状况与男性的Hhcy无显著关联，但与女性呈负相关。在两性中，当前吸烟状况和饮食习惯与Hhcy显著相关。我们的研究支持中国现行的关于保持身体活跃行为和健康生活方式习惯的建议。
