钯催化的炔丙基碳酸酯的区域发散性取代反应
Palladium-Catalyzed Regiodivergent Substitution of Propargylic Carbonates.
作者信息
Locascio Theresa M, Tunge Jon A
机构信息
Department of Chemistry, The University of Kansas, 2010 Malott Hall, 1251 Wescoe Hall Drive, Lawrence, KS, 66045, USA.
出版信息
Chemistry. 2016 Dec 12;22(50):18140-18146. doi: 10.1002/chem.201603481. Epub 2016 Oct 31.
PMID:27797416
Abstract
The palladium(0)-catalyzed, ligand-controlled, regioselective addition of diaryl acetonitrile pronucleophiles to propargylic carbonates is reported. Selective formation of either terminal 1,3-dienyl or propargylated products is proposed to arise from a change in reaction mechanism controlled by the denticity of the coordinating ligand.
摘要
据报道，钯（0）催化、配体控制、区域选择性地将二芳基乙腈亲核前体加成到炔丙基碳酸酯上。据推测，通过改变由配位配体的齿数控制的反应机理，可以选择性地生成末端1,3-二烯基产物或炔丙基化产物。
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