Ansink B J, Sarphatie H, van Dongen H R
Sint Lucas Ziekenhuis, Amsterdam, The Netherlands.
Neuropediatrics. 1989 Aug;20(3):170-2. doi: 10.1055/s-2008-1071285.
The Landau-Kleffner syndrome is an acquired condition in children consisting of aphasia and epileptic discharges in the EEG with or without clinical manifestation of epilepsy. We describe a case of a very young child whose neurologic and language development before onset of the illness was uniquely well documented. Apart from her aphasia she showed several other disturbances of higher cortical functions in the acute phase of the illness. No anatomical basis has been discovered for this disease till the present day. We discuss the possibility of an electrical dysregulation in several parts of the cortex as a pathophysiological basis for this syndrome.
Landau-Kleffner综合征是一种儿童后天性疾病，其特征为失语以及脑电图显示癫痫放电，癫痫可能有临床表现，也可能没有。我们描述了一个非常年幼孩子的病例，其发病前的神经和语言发育有非常详尽的记录。除失语外，她在疾病急性期还表现出其他几种高级皮质功能障碍。直到目前，尚未发现该疾病的解剖学基础。我们讨论了皮质多个部位电调节异常作为该综合征病理生理基础的可能性。
