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一名肾移植患者出现的依维莫司相关性口腔炎。

Everolimus-associated stomatitis in a patient who had renal transplant.

作者信息

Ji Yisi D, Aboalela Ali, Villa Alessandro

机构信息

Harvard School of Dental Medicine, Boston, Massachusetts, USA.

Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.

出版信息

BMJ Case Rep. 2016 Oct 19;2016:bcr2016217513. doi: 10.1136/bcr-2016-217513.

DOI:10.1136/bcr-2016-217513
PMID:27797804
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5073606/
Abstract

Everolimus is used as an immunosuppressant in renal allograft transplant rejection and in metastatic breast cancer treatment. One side effect of everolimus is stomatitis, referred to as mammalian target of rapamycin inhibitor-associated stomatitis. This side effect can affect treatment course and contribute to discontinuation of therapy or dose reduction, previously reported in the treatment of metastatic breast cancer. Here, we present a case of everolimus-associated stomatitis with a novel management method with intralesional triamcinolone that allows for continuous course of everolimus.

摘要

依维莫司被用作肾移植排斥反应的免疫抑制剂以及转移性乳腺癌的治疗药物。依维莫司的一个副作用是口腔炎，称为雷帕霉素抑制剂相关口腔炎。这种副作用会影响治疗进程，并导致治疗中断或剂量减少，此前在转移性乳腺癌治疗中已有报道。在此，我们报告一例依维莫司相关性口腔炎病例，采用病灶内注射曲安奈德的新管理方法，使依维莫司能够持续使用。

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本文引用的文献

1
Oral mucosal injury caused by mammalian target of rapamycin inhibitors: emerging perspectives on pathobiology and impact on clinical practice.雷帕霉素靶蛋白抑制剂所致口腔黏膜损伤：病理生物学新观点及其对临床实践的影响
Cancer Med. 2016 Aug;5(8):1897-907. doi: 10.1002/cam4.761. Epub 2016 Jun 23.
2
Meta-analysis of stomatitis in clinical studies of everolimus: incidence and relationship with efficacy.依维莫司临床研究中口腔炎的荟萃分析：发生率及其与疗效的关系。
Ann Oncol. 2016 Mar;27(3):519-25. doi: 10.1093/annonc/mdv595. Epub 2016 Jan 11.
3
Fewer cytomegalovirus complications after kidney transplantation by de novo use of mTOR inhibitors in comparison to mycophenolic acid.与霉酚酸相比，肾移植后重新使用mTOR抑制剂可减少巨细胞病毒并发症。
Transpl Infect Dis. 2016 Feb;18(1):79-88. doi: 10.1111/tid.12494. Epub 2016 Feb 3.
4
mTOR inhibitor-associated stomatitis (mIAS) in three patients with cancer treated with everolimus.三名接受依维莫司治疗的癌症患者发生的mTOR抑制剂相关口腔炎（mIAS）。
Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Jan;119(1):e13-9. doi: 10.1016/j.oooo.2014.08.023. Epub 2014 Sep 16.
5
Everolimus in liver transplantation.
Curr Opin Organ Transplant. 2014 Dec;19(6):578-82. doi: 10.1097/MOT.0000000000000127.
6
Mammalian target of rapamycin inhibitor-associated stomatitis.雷帕霉素靶蛋白抑制剂相关性口腔炎。
Future Oncol. 2013 Dec;9(12):1883-92. doi: 10.2217/fon.13.141.
7
Decreased incidence of cytomegalovirus infection with sirolimus in a post hoc randomized, multicenter study in lung transplantation.在后设随机、多中心肺移植研究中，西罗莫司降低巨细胞病毒感染的发生率。
J Heart Lung Transplant. 2013 Jul;32(7):701-6. doi: 10.1016/j.healun.2013.04.010. Epub 2013 May 7.
8
Oral ulcers in patients with advanced breast cancer receiving everolimus: a case series report on clinical presentation and management.晚期乳腺癌患者接受依维莫司治疗后出现口腔溃疡：临床特征和处理的病例系列报告。
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Aug;116(2):e110-6. doi: 10.1016/j.oooo.2013.02.022. Epub 2013 May 3.
9
Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial.依维莫司治疗结节性硬化症相关的血管平滑肌脂肪瘤或散发性淋巴管平滑肌瘤病（EXIST-2）：一项多中心、随机、双盲、安慰剂对照试验。
Lancet. 2013 Mar 9;381(9869):817-24. doi: 10.1016/S0140-6736(12)61767-X.
10
Is cytomegalovirus prophylaxis dispensable in patients receiving an mTOR inhibitor-based immunosuppression? a systematic review and meta-analysis.接受 mTOR 抑制剂为基础的免疫抑制治疗的患者中，巨细胞病毒预防是否可以省略？一项系统评价和荟萃分析。
Transplantation. 2012 Dec 27;94(12):1208-17. doi: 10.1097/TP.0b013e3182708e56.