Chen Wei Ren, Liu Hong Bin, Sha Yuan, Shi Yang, Wang Hao, Yin Da Wei, Chen Yun Dai, Shi Xiang Min
Department of South-Building Cardiology, PLA General Hospital, Beijing, China.
Department of South-Building Cardiology, PLA General Hospital, Beijing, China
J Am Heart Assoc. 2016 Oct 31;5(11):e003833. doi: 10.1161/JAHA.116.003833.
It has been reported that sleep deprivation is associated with cardiac autonomic disorder, inflammation, and oxidative stress. Statins have significant cardiovascular protective effects in patients with cardiovascular disease. This study aimed to investigate the protective effect of statins on arrhythmia and heart rate variability in young healthy persons after 48-hour sleep deprivation.
This study enrolled 72 young healthy participants aged 26.5±3.5 years. All participants received 48-hour continuous ambulatory electrocardiogram monitoring. Arrhythmia, time, and frequency domain parameters were analyzed for all participants. The primary end point, low/high frequency ratio, was significantly lower in the statin group than in the control group (2.48±1.12 versus 3.02±1.23, P<0.001). After 48-hour sleep deprivation, low frequency-the frequency of premature atrial complexes and premature ventricular complexes-was significantly decreased in the statin group compared with the control group (P<0.05). There was also a significant increase in high frequency in the statin group compared with the control group (P<0.05). There was a significant decrease in serum high-sensitivity C-reactive protein and malondialdehyde levels after 48-hour sleep deprivation in the statin group compared with the control group (P<0.05).
Statin use might be associated with improvement in arrhythmia and heart rate variability in healthy persons with 48-hour sleep deprivation. This finding should be confirmed by larger scale trials.
URL: http://www.clinicaltrials.gov. Unique identifier: NCT02496962.
据报道，睡眠剥夺与心脏自主神经功能紊乱、炎症及氧化应激有关。他汀类药物对心血管疾病患者具有显著的心血管保护作用。本研究旨在探讨他汀类药物对年轻健康人在48小时睡眠剥夺后心律失常及心率变异性的保护作用。
本研究纳入了72名年龄在26.5±3.5岁的年轻健康参与者。所有参与者均接受48小时动态心电图监测。对所有参与者的心律失常、时域和频域参数进行分析。主要终点指标，即低频/高频比值，他汀类药物组显著低于对照组（2.48±1.12对3.02±1.23，P<0.001）。在48小时睡眠剥夺后，与对照组相比，他汀类药物组的低频（房性早搏和室性早搏的频率）显著降低（P<0.05）。与对照组相比，他汀类药物组的高频也显著增加（P<0.05）。与对照组相比，他汀类药物组在48小时睡眠剥夺后血清高敏C反应蛋白和丙二醛水平显著降低（P<0.05）。
使用他汀类药物可能与改善48小时睡眠剥夺的健康人的心律失常及心率变异性有关。这一发现应通过更大规模的试验予以证实。
