Baldwin Melissa J, Policha Aleksandra, Maldonado Thomas, Hiramoto Jade S, Honig Stephen, Conte Michael S, Berger Jeffrey, Rockman Caron B
1 Division of Vascular & Endovascular Surgery, New York University Langone Medical Center, New York, NY, USA.
2 Division of Vascular & Endovascular Surgery, University of California San Francisco Medical Center, San Francisco, CA, USA.
Vasc Med. 2017 Feb;22(1):13-20. doi: 10.1177/1358863X16672740. Epub 2016 Oct 31.
The purpose of the current study was to investigate the association between bone mineral density (BMD) scores and the prevalence of peripheral artery disease (PAD) in a large cohort of subjects who underwent arterial Doppler assessments and calcaneal bone densitometry. The study was performed using data obtained from Life Line Screening Inc. Subjects were self-selected and paid for screening tests. The prevalence of PAD was significantly higher in men with osteopenia (4.5%) and osteoporosis (10.9%) compared to men with normal BMD (3.0%) ( p<0.001). Osteopenia (odds ratio (OR) 1.3) and osteoporosis (OR 2.3) were found to be independent risk factors for the presence of PAD in men. The prevalence of PAD was significantly higher in women with osteopenia (4.8%) and osteoporosis (11.8%) compared to women with normal BMD (3.3%) ( p<0.001). Osteopenia (OR 1.15) and osteoporosis (OR 1.8) were found to be independent risk factors for the presence of PAD in women. The current study reports a strong association of abnormal BMD analysis with the prevalence of PAD, which persists even when controlling for age and associated atherosclerotic risk factors. Although the mechanism by which these two disease processes is related is not completely elucidated, the presence of osteoporosis should make clinicians aware of the possibility of occult PAD or associated atherosclerotic disease in appropriate patients.
本研究的目的是在一大群接受动脉多普勒评估和跟骨骨密度测量的受试者中，调查骨矿物质密度（BMD）评分与外周动脉疾病（PAD）患病率之间的关联。该研究使用了从生命线筛查公司获得的数据。受试者是自我选择并支付筛查测试费用的。与骨密度正常的男性（3.0%）相比，骨质减少（4.5%）和骨质疏松（10.9%）的男性中PAD患病率显著更高（p<0.001）。骨质减少（比值比（OR）1.3）和骨质疏松（OR 2.3）被发现是男性患PAD的独立危险因素。与骨密度正常的女性（3.3%）相比，骨质减少（4.8%）和骨质疏松（11.8%）的女性中PAD患病率显著更高（p<0.001）。骨质减少（OR 1.15）和骨质疏松（OR 1.8）被发现是女性患PAD的独立危险因素。本研究报告了异常BMD分析与PAD患病率之间的强烈关联，即使在控制年龄和相关动脉粥样硬化危险因素时这种关联仍然存在。尽管这两种疾病过程相关的机制尚未完全阐明，但骨质疏松的存在应使临床医生意识到在合适的患者中存在隐匿性PAD或相关动脉粥样硬化疾病的可能性。
