Smallman Karen, Dickenson Anthony H, Halsey Michael J
HPNS Group, Division of Anaesthesia, Clinical Research Centre, Watford Road, Harrow, Middx HA1 3UJ U.K. Department of Pharmacology, University College London, Gower Street, London WC1E U.K.
Pain. 1989 Jul;38(1):57-64. doi: 10.1016/0304-3959(89)90073-0.
The purpose of this study was to investigate the effects, if any, of high pressure on opiate analgesia. The interaction of high pressure with intrathecal morphine (2.5-15 micrograms) and pethidine (10-145 micrograms) was studied on the responses of 51 dorsal horn neurones in the intact rat under urethane anaesthesia to electrical stimulation applied to their receptive fields. Two types of response to the addition of the opiates were found. Cells were either rapidly and maximally inhibited by the lowest dose of morphine (2.5 micrograms) or pethidine (10 micrograms) or slowly inhibited in a dose-dependent manner with an ED50 of 13.6 nmol for morphine and 401 nmol for pethidine. Pressure did not significantly affect the time-response curves for these two types of response but did change the relative numbers of each type recorded. The number of cells totally inhibited by the lowest of drug concentrations was increased for morphine at pressure but decreased for pethidine.
本研究的目的是调查高压对阿片类镇痛的影响（若有）。在乌拉坦麻醉下，研究了高压与鞘内注射吗啡（2.5 - 15微克）和哌替啶（10 - 145微克）对51只完整大鼠背角神经元对施加于其感受野的电刺激反应的相互作用。发现添加阿片类药物后有两种类型的反应。细胞要么被最低剂量的吗啡（2.5微克）或哌替啶（10微克）迅速且最大程度地抑制，要么以剂量依赖性方式缓慢抑制，吗啡的ED50为13.6纳摩尔，哌替啶的ED50为401纳摩尔。压力并未显著影响这两种类型反应的时间 - 反应曲线，但确实改变了记录的每种类型的相对数量。在压力下，被最低药物浓度完全抑制的吗啡处理的细胞数量增加，而哌替啶处理的细胞数量减少。
