Derosa Giuseppe, D'Angelo Angela, Romano Davide, Maffioli Pamela
Centre of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico S. Matteo, 2-27100 Pavia, Italy.
Center for Prevention, Surveillance, Diagnosis and Treatment of Rare Diseases, Fondazione IRCCS Policlinico S. Matteo, 2-27100 Pavia, Italy.
Int J Mol Sci. 2016 Oct 28;17(11):1802. doi: 10.3390/ijms17111802.
The aim of this study was to evaluate the effect of a food supplement containing α-lipoic acid and of a placebo on glyco-metabolic control and on oxidative stress markers in type 2 diabetics. We randomized 105 diabetics to either a supplementation containing 600 mg of α-lipoic acid, 165 mg of -carnosin, 7.5 mg of zinc, and vitamins of group B, or a placebo, for three months. We evaluated body mass index, fasting plasma glucose (FPG), post-prandial-glucose (PPG), glycated hemoglobin (HbA), fasting plasma insulin (FPI), HOMA-index (HOMA-IR), lipid profile, high sensitivity C-reactive protein (Hs-CRP), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA). There was a reduction of FPG, PPG, and HbA with the food supplement containing α-lipoic acid compared with a baseline, and with the placebo. Concerning lipid profile, we observed a reduction of LDL-C, and Tg with the food supplement, compared with both the baseline, and the placebo. There was a reduction of Hs-CRP with the food supplement containing α-lipoic acid, both compared with the baseline and the placebo. An increase of SOD, and GSH-Px, and a decrease of MDA were reached by the food supplement containing α-lipoic acid, both compared with the baseline and the placebo. We can conclude that the food supplement containing α-lipoic acid, -carnosin, zinc, and vitamins of group B improved glycemic control, lipid profile, and anti-oxidative stress markers.
本研究的目的是评估一种含α-硫辛酸的食品补充剂和一种安慰剂对2型糖尿病患者糖代谢控制及氧化应激标志物的影响。我们将105名糖尿病患者随机分为两组，一组服用含600毫克α-硫辛酸、165毫克肌肽、7.5毫克锌和B族维生素的补充剂，另一组服用安慰剂，为期三个月。我们评估了体重指数、空腹血糖（FPG）、餐后血糖（PPG）、糖化血红蛋白（HbA）、空腹血浆胰岛素（FPI）、HOMA指数（HOMA-IR）、血脂谱、高敏C反应蛋白（Hs-CRP）、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）、丙二醛（MDA）。与基线和安慰剂相比，含α-硫辛酸的食品补充剂使FPG、PPG和HbA降低。关于血脂谱，与基线和安慰剂相比，我们观察到该食品补充剂使低密度脂蛋白胆固醇（LDL-C）和甘油三酯（Tg）降低。与基线和安慰剂相比，含α-硫辛酸的食品补充剂使Hs-CRP降低。与基线和安慰剂相比，含α-硫辛酸的食品补充剂使SOD和GSH-Px升高，MDA降低。我们可以得出结论，含α-硫辛酸、肌肽、锌和B族维生素的食品补充剂改善了血糖控制、血脂谱和抗氧化应激标志物。
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