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止痛药物:急诊医学中阿片类药物的合理使用

Something for pain: Responsible opioid use in emergency medicine.

作者信息

Strayer Reuben J, Motov Sergey M, Nelson Lewis S

机构信息

79-01 Broadway, Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, Elmhurst, NY 11373, United States.

4802 Tenth Ave, Department of Emergency Medicine, Maimonides Medical Center, Brooklyn, NY 11219, United States.

出版信息

Am J Emerg Med. 2017 Feb;35(2):337-341. doi: 10.1016/j.ajem.2016.10.043. Epub 2016 Oct 24.

Abstract

The United States is currently experiencing a public health crisis of opioid addiction, which has its genesis in an industry marketing effort that successfully encouraged clinicians to prescribe opioids liberally, and asserted the safety of prescribing opioids for chronic non-cancer pain, despite a preponderance of evidence demonstrating the risks of dependence and misuse. The resulting rise in opioid use has pushed drug overdose deaths in front of motor vehicle collisions to become the leading cause of accidental death in the country. Emergency providers frequently treat patients for complications of opioid abuse, and also manage patients with acute and chronic pain, for which opioids are routinely prescribed. Emergency providers are therefore well positioned to both prevent new cases of opioid misuse and initiate appropriate treatment of existing opioid addicts. In opioid-naive patients, this is accomplished by a careful consideration of the likelihood of benefit and harm of an opioid prescription for acute pain. If opioids are prescribed, the chance of harm is reduced by matching the number of pills prescribed to the expected duration of pain and selecting an opioid preparation with low abuse liability. Patients who present to acute care with exacerbations of chronic pain or painful conditions associated with opioid misuse are best managed by treating symptoms with opioid alternatives and encouraging treatment for opioid addiction.

摘要

美国目前正经历一场阿片类药物成瘾的公共卫生危机,这场危机源于一场行业营销活动,该活动成功地鼓励临床医生大量开具阿片类药物,并宣称开具阿片类药物治疗慢性非癌性疼痛是安全的,尽管大量证据表明存在依赖和滥用风险。由此导致的阿片类药物使用量上升,使药物过量死亡超过机动车碰撞,成为该国意外死亡的主要原因。急诊医护人员经常治疗阿片类药物滥用并发症患者,也管理急性和慢性疼痛患者,而阿片类药物通常用于这些患者的治疗。因此,急诊医护人员在预防阿片类药物新的滥用病例和对现有阿片类药物成瘾者进行适当治疗方面具有良好的条件。对于未使用过阿片类药物的患者,这可以通过仔细考虑阿片类药物处方对急性疼痛的获益和危害可能性来实现。如果开具阿片类药物,通过根据预期疼痛持续时间匹配所开药丸数量并选择滥用可能性低的阿片类药物制剂来降低危害几率。因慢性疼痛加重或与阿片类药物滥用相关的疼痛状况而前来接受急性治疗的患者,最好通过使用阿片类药物替代品治疗症状并鼓励对阿片类药物成瘾进行治疗来进行管理。

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