Bezzio Cristina, Fascì-Spurio Federica, Viganò Chiara, Meucci Gianmichele, Papi Claudio, Saibeni Simone
a Gastroenterology Unit , Rho Hospital, ASST Rhodense , Garbagnate Milanese , Italy.
b Internal Medicine Unit , dell'Angelo Hospital , Mestre , Italy.
Expert Rev Gastroenterol Hepatol. 2017 Jan;11(1):33-41. doi: 10.1080/17474124.2017.1256200. Epub 2016 Nov 14.
Ulcerative colitis (uc) is a chronic condition and for the vast majority of patients, life-long treatment is required. low adherence to therapy is an emerging issue. since low adherence is associated with poor clinical outcomes and increased costs, it is becoming crucial to identify strategies in order to improve it. Areas covered: We performed literature searches in PubMed using the terms 'adherence', 'mesalamine', 'budesonide MMX', 'MMX technology' in combination with 'ulcerative colitis'. Firstly, we present the key-concepts of therapy for UC and discuss the problem of the adherence and how to measure it. Then, we provide data on the extent of the problem and the causes and consequences from clinical and economic point of views. Finally, we focus on treatment-related variables associated with non-adherence and treatment-related strategies to improve adherence, paying particular attention to Multi Matrix system (MMX) technology applied to mesalazine and budesonide. Expert commentary: The pharmaceutical industry and scientific community are making efforts to simplify treatments for UC. MMX technology, which allows a reduction in the number of pills to be taken and daily administrations, may facilitate adherence to treatment and carry further clinical benefits.
溃疡性结肠炎（UC）是一种慢性疾病，对于绝大多数患者来说，需要终身治疗。治疗依从性低是一个新出现的问题。由于低依从性与不良临床结局和成本增加相关，确定改善依从性的策略变得至关重要。涵盖领域：我们在PubMed中使用“依从性”“美沙拉嗪”“布地奈德MMX”“MMX技术”与“溃疡性结肠炎”相结合的术语进行文献检索。首先，我们介绍UC治疗的关键概念，讨论依从性问题以及如何衡量它。然后，我们从临床和经济角度提供关于该问题的程度、原因及后果的数据。最后，我们关注与不依从相关的治疗相关变量以及改善依从性的治疗相关策略，特别关注应用于美沙拉嗪和布地奈德的多矩阵系统（MMX）技术。专家评论：制药行业和科学界正在努力简化UC的治疗。MMX技术可减少服药数量和每日给药次数，可能有助于提高治疗依从性并带来更多临床益处。
