Dias-Carneiro Rafael P C, von Glehn Felipe, Moraes Adriel S, Boldrini Vinícius O, Damasceno Alfredo, Andrade Marilia D, Lima Alliny C D, Casanova Cristiane S, Tilbery Charles P, Damasceno Benito P, Santos Leonilda Mb Dos, Brandão Carlos O
Neuroimmunology Unit, University of Campinas, Campinas, Brazil; CATEM - Multiple Sclerosis Care Center, Santa Casa de São Paulo, São Paulo, Brazil.
Neuroimmunology Unit, University of Campinas, Campinas, Brazil; Department of Neurology, Brigham and Women's Hospital, Ann Romney Center for Neurologic Diseases, Harvard Medical School, Boston, USA.
J Neuroimmunol. 2016 Nov 15;300:30-35. doi: 10.1016/j.jneuroim.2016.10.001. Epub 2016 Oct 5.
Given the low detection rates of CSF IgG-Oligoclonal bands (IgG-OCB) in non-European Multiple Sclerosis (MS) patients and higher specificity of the MRZH-reaction, we evaluated whether associating MRZH-reaction to CSF IgG-OCB detection improved investigation of suspected MS. Paired CSF and sera were analyzed for IgG-OCB and polyspecific viral antibodies. IgG-OCB were detected in 72% of MS patients and an MRZH-reaction in 67%. Combining IgG-OCB and MRZH raised detection of IgG abnormalities to 97% of studied MS patients. Detection of IgG-OCB and/or ≥2 MRZH antibodies showed sensitivity of 88% and specificity of 92% for MS, versus 72% and 96% for IgG-OCB alone.
鉴于非欧洲多发性硬化症（MS）患者脑脊液IgG寡克隆带（IgG-OCB）的低检出率以及MRZH反应的更高特异性，我们评估了将MRZH反应与脑脊液IgG-OCB检测相结合是否能改善对疑似MS的检查。对配对的脑脊液和血清进行IgG-OCB和多特异性病毒抗体分析。72%的MS患者检测到IgG-OCB，67%检测到MRZH反应。将IgG-OCB和MRZH相结合，使所研究的MS患者中IgG异常的检出率提高到97%。检测IgG-OCB和/或≥2种MRZH抗体对MS的敏感性为88%，特异性为92%，而单独检测IgG-OCB时敏感性为72%，特异性为96%。
